| Gene Symbol |
CUL4B
|
| Entrez Gene |
8450
|
| Alt Symbol |
CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cullin 4B
|
| Other Description |
cullin-4B
|
| Swissprots |
Q9UED7 Q13620 Q9UEB7 Q6PIE4 B1APK5 Q6UP07 B3KVX4 Q7Z673 B7Z5K8 Q9BY37
|
| Accessions |
AAB67315 EAX11876 EAX11877 EAX11878 EAX11879 EAX11880 Q13620 AB014595 BAA31670 AF212995 AAK16812 AK123688 BAG53936 AK299081 BAH12944 AK315037 BAG37520 AY365125 AAR13073 BC036216 AAH36216 BX537641 BX537787 CAD97843 BX647096 CR936722 CV573599 DB092748 DQ894750 ABM85676 U58091 AAC50548 XM_005262481 XP_005262538 XM_006724784 XP_006724847 XM_006724785 XP_006724848 XM_011531399 XP_011529701 XM_011531400 XP_011529702 XM_011531401 XP_011529703 NM_001079872 NP_001073341 NM_003588 NP_003579
|
| Function |
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation- induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19801544}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Nucleotide excision repair
|