CUL4B

Gene Symbol	CUL4B
Entrez Gene	8450
Alt Symbol	CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2
Species	Human
Gene Type	protein-coding
Description	cullin 4B
Other Description	cullin-4B
Swissprots	Q9UED7 Q13620 Q9UEB7 Q6PIE4 B1APK5 Q6UP07 B3KVX4 Q7Z673 B7Z5K8 Q9BY37
Accessions	AAB67315 EAX11876 EAX11877 EAX11878 EAX11879 EAX11880 Q13620 AB014595 BAA31670 AF212995 AAK16812 AK123688 BAG53936 AK299081 BAH12944 AK315037 BAG37520 AY365125 AAR13073 BC036216 AAH36216 BX537641 BX537787 CAD97843 BX647096 CR936722 CV573599 DB092748 DQ894750 ABM85676 U58091 AAC50548 XM_005262481 XP_005262538 XM_006724784 XP_006724847 XM_006724785 XP_006724848 XM_011531399 XP_011529701 XM_011531400 XP_011529702 XM_011531401 XP_011529703 NM_001079872 NP_001073341 NM_003588 NP_003579
Function	Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation- induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway
Subcellular Location	Nucleus {ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19801544}.
Top Pathways	Ubiquitin mediated proteolysis, Nucleotide excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cullin 4B full length protein - ab160035 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human CUL4B Protein - H00008450-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Cullin-4B - H00008450-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Cullin-4B - H00008450-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CUL4B fusion protein - Ag15441 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

CUL4B fusion protein - ag3563 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CUL4B fusion protein - Ag15024 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

CUL4B fusion protein - ag17727 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human CUL4B, His-tagged - CUL4B-11705H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Cullin-4B(CUL4B) ,partial - CSB-YP615708HU CSB-EP615708HU CSB-BP615708HU CSB-MP615708HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Cullin-4B (transcript variant 1) - TP306935 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CUL4B Recombinant Protein Antigen - NBP1-86099PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Cullin 4B Blocking Peptide - abx061891 from Abbexa Category Peptide

CUL4B-Blocking-Peptide-Center - BP20232c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CUL4B Peptide, Human - M34GP03842H from Creative Peptides Category Peptide Source Synthetic. Species Human

Cullin 4B Blocking Peptide - CBP7281 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

CUL4B Recombinant Protein Antigen - NBP2-56697PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Cullin-4B (CUL4B), partial, Recombinant Protein - MBS1473051 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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