KLK14

Gene Symbol	KLK14
Entrez Gene	43847
Alt Symbol	KLK-L6
Species	Human
Gene Type	protein-coding
Description	kallikrein-related peptidase 14
Other Description	hK14|kallikrein 14|kallikrein-14|kallikrein-like protein 6
Swissprots	Q6B089 A7UNK5 Q9P0G3 Q1RMZ2
Accessions	AAD50773 AAG23260 AAK48523 ABU63131 EAW71982 EAW71983 Q9P0G3 AF283670 AAK48524 BC074904 AAH74904 BC074905 AAH74905 BC114614 AAI14615 XM_011526984 XP_011525286 XM_011526985 XP_011525287 NM_022046 NP_071329
Function	Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. {ECO:0000269|PubMed:15654974, ECO:0000269|PubMed:16885167, ECO:0000269|PubMed:17158887, ECO:0000269|PubMed:17625593, ECO:0000269|PubMed:18056261, ECO:0000269|PubMed:18482984}.
Subcellular Location	Secreted, extracellular space {ECO:0000269|PubMed:15654974, ECO:0000269|PubMed:16456535, ECO:0000269|PubMed:17110383}.
Tissue Specificity	Highly expressed in CNS, bone marrow and fetal liver. Also expressed in breast, thyroid, kidney, colon, pancreas, spleen, prostate, uterus, small intestine, placenta and skeletal muscle. Among 40 tissues tested, the highest expression is detected in skin followed by breast and prostate (at protein level). Expressed in stratum corneum by sweat ducts and sweat glands and detected in sweat (at protein level). {ECO:0000269|PubMed:10969073, ECO:0000269|PubMed:11309303, ECO:0000269|PubMed:11352573, ECO:0000269|PubMed:16456535, ECO:0000269|PubMed:16800737, ECO:0000269|PubMed:17110383}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Kallikrein 14 full length protein - ab162330 from Abcam Category Protein Source Wheat germ Species Human

Human Kallikrein 14 protein fragment - ab162331 from Abcam Category Protein Source Wheat germ Species Human

Kallikrein 14 peptide - ab41399 from Abcam Category Peptide

Kallikrein 14 peptide - ab43111 from Abcam Category Peptide

KLK14 / Kallikrein 14 Antibody Blocking Peptide - LS-E3618 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Kallikrein 14 Protein - H00043847-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Kallikrein 14 Protein - H00043847-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

KLK14-Antibody-N-term-Blocking-Peptide - BP14824a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Kallikrein 14, CF - 2626-SE-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gln19-Met248, with a C-terminal 10-His tag

KLK14 / Kallikrein-14 - H00043847-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

KLK14 / Kallikrein-14 - H00043847-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

KLK14 / Kallikrein-14 - H00043847-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

KLK14 fusion protein - ag12459 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

KLK14 fusion protein - ag12561 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human KLK14, His-tagged - KLK14-274H from Creative Biomart Category Protein Source NSO cells Species Human

Recombinant Kallikrein 14 (KLK14) - RPD374Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Kallikrein 14 (KLK14) - RPD374Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Kallikrein-14(KLK14) - CSB-YP868375HU CSB-EP868375HU CSB-BP868375HU CSB-MP868375HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Kallikrein 14 Protein, CF - 2626-SE from R&D Systems Category Protein Prices $329.00 Sizes 10 µg Source Mouse myeloma cell line, NS0-derived Gln19-Met248, with a C-terminal 10-His tag Species Human

Kallikrein 14 Protein (Recombinant) - abx168213 from Abbexa Category Protein Source Human Species Human

KLK14-Antibody-C-term-Blocking-Peptide - BP6333b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KLK14-Antibody-Center-Blocking-Peptide - BP6333a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KLK14 Peptide, Human - M34GP08307H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Kallikrein 14 (KLK14) - RPU52872 from Biomatik Category Protein Prices $192.00, $392.00, $600.00, $715.04 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

KLK14 Recombinant Protein (OPCD04694) - OPCD04694 from Aviva Systems Biology Category Protein Source E.coli Species Human

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