Gene Symbol | THEM5 |
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Entrez Gene | 284486 |
Alt Symbol | ACOT15 |
Species | Human |
Gene Type | protein-coding |
Description | thioesterase superfamily member 5 |
Other Description | acyl-CoA thioesterase THEM5|acyl-coenzyme A thioesterase 15|acyl-coenzyme A thioesterase THEM5 |
Swissprots | Q5T1C3 Q8N1Q8 |
Accessions | EAW53404 Q8N1Q8 AK095283 BAC04521 BC101610 AAI01611 BC112239 AAI12240 HQ258137 ADR82891 XM_011509421 XP_011507723 NM_182578 NP_872384 |
Function | Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function. {ECO:0000269|PubMed:22586271}. |
Subcellular Location | Mitochondrion matrix {ECO:0000269|PubMed:22586271}. |
THEM5 CRISPR/Cas9 KO Plasmid (h) - sc-408384 from Santa Cruz Biotechnology
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THEM5 HDR Plasmid (h) - sc-408384-HDR from Santa Cruz Biotechnology
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THEM5 Double Nickase Plasmid (h) - sc-408384-NIC from Santa Cruz Biotechnology
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THEM5 Double Nickase Plasmid (h2) - sc-408384-NIC-2 from Santa Cruz Biotechnology
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THEM5 CRISPR Activation Plasmid (h) - sc-408384-ACT from Santa Cruz Biotechnology
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THEM5 CRISPR Activation Plasmid (h2) - sc-408384-ACT-2 from Santa Cruz Biotechnology
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THEM5 Lentiviral Activation Particles (h) - sc-408384-LAC from Santa Cruz Biotechnology
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THEM5 Lentiviral Activation Particles (h2) - sc-408384-LAC-2 from Santa Cruz Biotechnology
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THEM5 siRNA (h) - sc-88507 from Santa Cruz Biotechnology
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THEM5 shRNA Plasmid (h) - sc-88507-SH from Santa Cruz Biotechnology
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THEM5 shRNA (h) Lentiviral Particles - sc-88507-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU138181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21309 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21309 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09822 from Sigma-Aldrich
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THEM5 siRNA (Human) - CRJ7035 from Cohesion Biosciences
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THEM5 - MBS8225799 from MyBioSource
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shRNA set against Human THEM5 (NM_182578.3) - SHH426852 from Creative biogene
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Human THEM5 siRNA - orb277536 from Biorbyt
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THEM5 shRNA Plasmid (Human) - CHJ7035 from Cohesion Biosciences
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THEM5 miRNA 3'UTR clone - MiUTR4H-TG08954 from Creative biogene
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