Gene Symbol | CHST5 |
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Entrez Gene | 23563 |
Alt Symbol | I-GlcNAc-6-ST, I-GlcNAc6ST, glcNAc6ST-3, gn6st-3, hIGn6ST |
Species | Human |
Gene Type | protein-coding |
Description | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 |
Other Description | GST4-alpha|N-acetylglucosamine 6-O-sulfotransferase 3|carbohydrate sulfotransferase 5|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha|intestinal GlcNAc-6-sulfotransferase |
Swissprots | Q9GZS9 B2RV23 Q9UBY3 Q7LCN3 |
Accessions | AAD56001 AAG26326 EAW95635 EAW95636 Q9GZS9 AF246718 AAG28023 BC147002 AAI47003 BC147007 AAI47008 BX282540 HQ448069 ADQ32550 NM_024533 NP_078809 NM_012126 |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location. {ECO:0000269|PubMed:10491328, ECO:0000269|PubMed:11352640, ECO:0000269|PubMed:12218059, ECO:0000269|PubMed:12626414}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000305|PubMed:12855678}; Single-pass type II membrane protein {ECO:0000305|PubMed:12855678}. Note=Golgi membrane, early secretory pathway. |
Tissue Specificity | Predominantly expressed in small and large intestines and colon. Weakly expressed in lymphocytes. Not expressed in other tissues. Down-regulated in colonic adenocarcinomas. {ECO:0000269|PubMed:10491328, ECO:0000269|PubMed:11017086, ECO:0000269|PubMed:11352640, ECO:0000269|PubMed:12107080, ECO:0000269|PubMed:12626414}. |
Anti-CHST5 antibody - ab118108 from Abcam
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Anti-CHST5 antibody - C-terminal - ab139121 from Abcam
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Anti-CHST5 Antibody (aa275-302, AP) - LS-C208451 from LifeSpan Bioscience
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Anti-CHST5 Antibody (aa28-390) - LS-C125249 from LifeSpan Bioscience
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Anti-CHST5 Antibody (aa275-302, APC) - LS-C208452 from LifeSpan Bioscience
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Anti-CHST5 Antibody (aa275-302, FITC) - LS-C208454 from LifeSpan Bioscience
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Anti-CHST5 Antibody (aa275-302, Azide-free, HRP) - LS-C208455 from LifeSpan Bioscience
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Anti-CHST5 Antibody (aa275-302, PE) - LS-C208456 from LifeSpan Bioscience
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Anti-CHST5 Antibody (aa275-302, Biotin) - LS-C208453 from LifeSpan Bioscience
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Anti-CHST5 Antibody (aa310-391) - LS-C307798 from LifeSpan Bioscience
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Anti-CHST5 Antibody (aa275-302) - LS-C159351 from LifeSpan Bioscience
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Anti-CHST5 Antibody (aa275-302) - LS-C320385 from LifeSpan Bioscience
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Carbohydrate Sulfotransferase 5/CHST5 Antibody - AF5446 from Novus Biologicals
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Carbohydrate Sulfotransferase 5/CHST5 Antibody - NBP1-91785 from Novus Biologicals
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Carbohydrate Sulfotransferase 5/CHST5 Antibody (2E6) - H00023563-M05 from Novus Biologicals
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Monoclonal Anti-CHST5, (C-terminal) antibody produced in mouse - SAB1403151 from Sigma-Aldrich
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CHST5-Antibody-C-term - AP18949b from Abgent, a WuXi AppTec company
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Chst5-mouse-Antibody-C-Term - AF2910a from Abgent, a WuXi AppTec company
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CHST5/6 antibody [N1C3] - GTX110290 from GeneTex
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CHST5 Antibody - C-terminal region (OAAB14487) - OAAB14487 from Aviva Systems Biology
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Human Carbohydrate Sulfotransferase 5/CHST5 Antibody - AF5446 from R&D Systems
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Human CHST5 Affinity Purified Polyclonal Ab, Goat IgG - AF5446-SP from R&D Systems
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Anti -CHST5 (Carbohydrate sulfotransferase 5,Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha, IntestinalN-acetylglucosamine-6-O-sulfotransferase, N-acetylglucosamine 6-O-sulfotransferase 3) - 124989 from USBiological Life Science
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Anti -CHST5 (Carbohydrate sulfotransferase 5,Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha, IntestinalN-acetylglucosamine-6-O-sulfotransferase, N-acetylglucosamine 6-O-sulfotransferase 3) (AP) - 124989-AP from USBiological Life Science
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Anti -CHST5 (Carbohydrate sulfotransferase 5,Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha, IntestinalN-acetylglucosamine-6-O-sulfotransferase, N-acetylglucosamine 6-O-sulfotransferase 3)(Biotin) - 124989-Biotin from USBiological Life Science
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