| Gene Symbol |
CHST5
|
| Entrez Gene |
23563
|
| Alt Symbol |
I-GlcNAc-6-ST, I-GlcNAc6ST, glcNAc6ST-3, gn6st-3, hIGn6ST
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
|
| Other Description |
GST4-alpha|N-acetylglucosamine 6-O-sulfotransferase 3|carbohydrate sulfotransferase 5|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha|intestinal GlcNAc-6-sulfotransferase
|
| Swissprots |
Q9GZS9 B2RV23 Q9UBY3 Q7LCN3
|
| Accessions |
AAD56001 AAG26326 EAW95635 EAW95636 Q9GZS9 AF246718 AAG28023 BC147002 AAI47003 BC147007 AAI47008 BX282540 HQ448069 ADQ32550 NM_024533 NP_078809 NM_012126
|
| Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location. {ECO:0000269|PubMed:10491328, ECO:0000269|PubMed:11352640, ECO:0000269|PubMed:12218059, ECO:0000269|PubMed:12626414}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000305|PubMed:12855678}; Single-pass type II membrane protein {ECO:0000305|PubMed:12855678}. Note=Golgi membrane, early secretory pathway.
|
| Tissue Specificity |
Predominantly expressed in small and large intestines and colon. Weakly expressed in lymphocytes. Not expressed in other tissues. Down-regulated in colonic adenocarcinomas. {ECO:0000269|PubMed:10491328, ECO:0000269|PubMed:11017086, ECO:0000269|PubMed:11352640, ECO:0000269|PubMed:12107080, ECO:0000269|PubMed:12626414}.
|
