Gene Symbol | CHST5 |
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Entrez Gene | 23563 |
Alt Symbol | I-GlcNAc-6-ST, I-GlcNAc6ST, glcNAc6ST-3, gn6st-3, hIGn6ST |
Species | Human |
Gene Type | protein-coding |
Description | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 |
Other Description | GST4-alpha|N-acetylglucosamine 6-O-sulfotransferase 3|carbohydrate sulfotransferase 5|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha|intestinal GlcNAc-6-sulfotransferase |
Swissprots | Q9GZS9 B2RV23 Q9UBY3 Q7LCN3 |
Accessions | AAD56001 AAG26326 EAW95635 EAW95636 Q9GZS9 AF246718 AAG28023 BC147002 AAI47003 BC147007 AAI47008 BX282540 HQ448069 ADQ32550 NM_024533 NP_078809 NM_012126 |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location. {ECO:0000269|PubMed:10491328, ECO:0000269|PubMed:11352640, ECO:0000269|PubMed:12218059, ECO:0000269|PubMed:12626414}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000305|PubMed:12855678}; Single-pass type II membrane protein {ECO:0000305|PubMed:12855678}. Note=Golgi membrane, early secretory pathway. |
Tissue Specificity | Predominantly expressed in small and large intestines and colon. Weakly expressed in lymphocytes. Not expressed in other tissues. Down-regulated in colonic adenocarcinomas. {ECO:0000269|PubMed:10491328, ECO:0000269|PubMed:11017086, ECO:0000269|PubMed:11352640, ECO:0000269|PubMed:12107080, ECO:0000269|PubMed:12626414}. |
CHST5 CRISPR/Cas9 KO Plasmid (h) - sc-411767 from Santa Cruz Biotechnology
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CHST5 HDR Plasmid (h) - sc-411767-HDR from Santa Cruz Biotechnology
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CHST5 Double Nickase Plasmid (h) - sc-411767-NIC from Santa Cruz Biotechnology
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CHST5 Double Nickase Plasmid (h2) - sc-411767-NIC-2 from Santa Cruz Biotechnology
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CHST5 CRISPR Activation Plasmid (h) - sc-411767-ACT from Santa Cruz Biotechnology
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CHST5 CRISPR Activation Plasmid (h2) - sc-411767-ACT-2 from Santa Cruz Biotechnology
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CHST5 Lentiviral Activation Particles (h) - sc-411767-LAC from Santa Cruz Biotechnology
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CHST5 Lentiviral Activation Particles (h2) - sc-411767-LAC-2 from Santa Cruz Biotechnology
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CHST5 siRNA (h) - sc-62118 from Santa Cruz Biotechnology
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CHST5 shRNA Plasmid (h) - sc-62118-SH from Santa Cruz Biotechnology
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CHST5 shRNA (h) Lentiviral Particles - sc-62118-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU100131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6113 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6113 from Sigma-Aldrich
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CHST5 siRNA (Human) - CRH8364 from Cohesion Biosciences
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CHST5 - MBS8203903 from MyBioSource
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Human CHST5 siRNA - orb268866 from Biorbyt
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CHST5 shRNA Plasmid (Human) - CHH8364 from Cohesion Biosciences
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CHST5 miRNA 3'UTR clone - MiUTR3H-07116 from Creative biogene
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