ERBB2

Gene Symbol	ERBB2
Entrez Gene	2064
Alt Symbol	CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Species	Human
Gene Type	protein-coding
Description	erb-b2 receptor tyrosine kinase 2
Other Description	c-erb B2/neu protein|herstatin|human epidermal growth factor receptor 2|metastatic lymph node gene 19 protein|neuro/glioblastoma derived oncogene homolog|neuroblastoma/glioblastoma derived oncogene homolog|p185erbB2|proto-oncogene Neu|proto-oncogene c-ErbB-2|receptor tyrosine-protein kinase erbB-2|tyrosine kinase-type cell surface receptor HER2|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2|v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2|v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Swissprots	B4DHN3 B2RZG3 Q9UMK4 X5D2V5 Q6LDV1 Q14256 P04626
Accessions	AAA35809 AAA35978 AAA58637 AAC37531 AAD15229 AAF30295 AAO18082 BAE15959 BAE15960 CCA94568 CCQ77584 EAW60595 EAW60596 EAW60597 P04626 AB025286 AF177761 AAD56009 AK131568 AK295195 BAG58195 AK296908 BAG59464 AK300321 BAG62073 AK309029 AK313683 BC080193 BC110392 BC156755 AAI56756 BC167147 AAI67147 BI755753 BM678576 CN409735 DC346286 HM437238 ADN43069 HY033940 KJ534831 AHW56471 KJ534832 AHW56472 KJ534964 AHW56604 M11730 AAA75493 S57296 AAD14920 X03363 CAA27060 NM_001005862 NP_001005862 NM_001289936 NP_001276865 NM_001289937 NP_001276866 NM_001289938 NP_001276867 NM_004448 NP_004439 NR_110535
Function	Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Subcellular Location	Isoform 3: Cytoplasm. Nucleus.
Tissue Specificity	Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. {ECO:0000269|PubMed:15380516}.
Top Pathways	Proteoglycans in cancer, MicroRNAs in cancer, Central carbon metabolism in cancer, Adherens junction, Calcium signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat ErbB2/Her2 (AAH61863) VersaClone cDNA - RDC0475 from R&D Systems Prices $799.00 Sizes 10 µg Species Rat

Human ErbB2/Her2 (NP_004439) VersaClone cDNA - RDC1022 from R&D Systems Prices $799.00 Sizes 10 µg Species Human

Mouse ErbB2/Her2 (NP_001003817) VersaClone cDNA - RDC1103 from R&D Systems Prices $799.00 Sizes 10 µg Species Mouse

Human ErbB2/Her2 (NP_001005862) VersaClone cDNA - RDC1023 from R&D Systems Prices $799.00 Sizes 10 µg Species Human

Human ERBB2 cDNA clone(NM_001005862.1) - CDFH006039 from Creative Biomart Species Human Accession NM_001005862.1

Human ERBB2 cDNA clone(NM_004448.2) - CDFH006040 from Creative Biomart Species Human Accession NM_004448.2

Human ERBB2 cDNA clone(NM_004448.2) - CDFH006041 from Creative Biomart Species Human Accession NM_004448.2

Human ERBB2 cDNA clone(NM_004448.2) - CDFH006042 from Creative Biomart Species Human Accession NM_004448.2

Human ERBB2 ORF Clone(NM_001005862.1) - CDCR339938 from Creative Biomart Species Human Accession NM_001005862.1

Human ERBB2 ORF Clone(NM_001005862.1) - CDCR339939 from Creative Biomart Species Human Accession NM_001005862.1

Human ERBB2 ORF Clone(NM_004448.2) - CDCL162541 from Creative Biomart Species Human Accession NM_004448.2

Human ErbB2 ORF clone(NM_004448.2) - CDCL184095 from Creative Biomart Species Human Accession NM_004448.2

Human ERBB2 ORF Clone(NM_004448.2) - CDCR288034 from Creative Biomart Species Human Accession NM_004448.2

Human ERBB2 ORF Clone(NM_004448.2) - CDCR288036 from Creative Biomart Species Human Accession NM_004448.2

Human HER2/ERBB2 transcript variant 1 Gene ORF cDNA clone in cloning vector - HG10004-M from Sino Biological Species Human

Human HER2/ERBB2 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10004-CM from Sino Biological Species Human

Human HER2/ERBB2 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10004-NH from Sino Biological Species Human

Human HER2/ERBB2 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10004-ACR from Sino Biological Species Human

Human HER2/ERBB2 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10004-CY from Sino Biological Species Human

Human HER2/ERBB2 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10004-CH from Sino Biological Species Human

Human HER2/ERBB2 transcript variant 1 Gene ORF cDNA clone expression plasmid - HG10004-UT from Sino Biological Species Human

Human HER2/ERBB2 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10004-NY from Sino Biological Species Human

Human HER2/ERBB2 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10004-ACG from Sino Biological Species Human

Human HER2/ERBB2 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10004-CF from Sino Biological Species Human

Human HER2/ERBB2 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10004-NF from Sino Biological Species Human

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