ERBB2

Gene Symbol ERBB2
Entrez Gene 2064
Alt Symbol CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Species Human
Gene Type protein-coding
Description erb-b2 receptor tyrosine kinase 2
Other Description c-erb B2/neu protein|herstatin|human epidermal growth factor receptor 2|metastatic lymph node gene 19 protein|neuro/glioblastoma derived oncogene homolog|neuroblastoma/glioblastoma derived oncogene homolog|p185erbB2|proto-oncogene Neu|proto-oncogene c-ErbB-2|receptor tyrosine-protein kinase erbB-2|tyrosine kinase-type cell surface receptor HER2|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2|v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2|v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Swissprots B4DHN3 B2RZG3 Q9UMK4 X5D2V5 Q6LDV1 Q14256 P04626
Accessions AAA35809 AAA35978 AAA58637 AAC37531 AAD15229 AAF30295 AAO18082 BAE15959 BAE15960 CCA94568 CCQ77584 EAW60595 EAW60596 EAW60597 P04626 AB025286 AF177761 AAD56009 AK131568 AK295195 BAG58195 AK296908 BAG59464 AK300321 BAG62073 AK309029 AK313683 BC080193 BC110392 BC156755 AAI56756 BC167147 AAI67147 BI755753 BM678576 CN409735 DC346286 HM437238 ADN43069 HY033940 KJ534831 AHW56471 KJ534832 AHW56472 KJ534964 AHW56604 M11730 AAA75493 S57296 AAD14920 X03363 CAA27060 NM_001005862 NP_001005862 NM_001289936 NP_001276865 NM_001289937 NP_001276866 NM_001289938 NP_001276867 NM_004448 NP_004439 NR_110535
Function Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Subcellular Location Isoform 3: Cytoplasm. Nucleus.
Tissue Specificity Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. {ECO:0000269|PubMed:15380516}.
Top Pathways Proteoglycans in cancer, MicroRNAs in cancer, Central carbon metabolism in cancer, Adherens junction, Calcium signaling pathway

PathScan ® Phospho-HER2/ErbB2 (Tyr1221/1222) Sandwich ELISA Antibody Pair - 7817 from Cell Signaling Technology

Category Antibody Pair
Prices $459.00
Sizes 1 kit (Reagents for 4 x 96 well plates)

PathScan® Phospho-HER2/ErbB2 (Tyr1221/1222) Sandwich ELISA Kit - 7148 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

PathScan ® Phospho-HER2/ErbB2 (panTyr) Sandwich ELISA Kit - 7968 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

PathScan ® Total HER2/ErbB2 Sandwich ELISA Kit - 7310 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

HTScan® HER2/ErbB2 Kinase Assay Kit - 7058 from Cell Signaling Technology

Category Assay Kit
Figure 1. HER2/ErbB2 kinase activity was measured in a radiometric assay using the following reaction conditions: 5 mM MOPS, pH 7.2, 2.5 mM β-glycerophosphate, 5 mM MnCl2, 1 mM EGTA, 0.4 mM EDTA, 4 mM MgCl2, 0.05 mM DTT, 50 μM ATP, Substrate: Poly(Glu-Tyr), 400 ng/μL, and recombinant HER2/ErbB2: variable.

ErbB2 Human ELISA Kit - ab100510 from Abcam

Category ELISA Kit
Prices $489.00
Sizes 1 x 96 tests
Sensitivity < 8 pg/ml
Range 8.19 pg/ml - 2000 pg/ml
Representative Standard Curve using ab100510.

Mouse ERBB2 / HER2 ELISA Kit (Sandwich ELISA) - LS-F5689 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity 0.207 ng/ml
Range 8.19-2000 pg/ml

Human ERBB2 / HER2 ELISA Kit (Sandwich ELISA) - LS-F2667 from LifeSpan Bioscience

Category ELISA Kit
Prices $570.00
Sizes 1 plate
Sensitivity 10 pg/ml
Range 8.19-2000 pg/ml

Human ERBB2 / HER2 ELISA Kit (Sandwich ELISA) - LS-F5037 from LifeSpan Bioscience

Category ELISA Kit
Prices $690.00
Sizes 1 plate
Sensitivity 0.625 ng/ml
Range 8.19-2000 pg/ml

Rat ERBB2 / HER2 ELISA Kit (Sandwich ELISA) - LS-F5857 from LifeSpan Bioscience

Category ELISA Kit
Prices $740.00
Sizes 1 plate
Sensitivity 0.221 ng/ml
Range 8.19-2000 pg/ml

Mouse/Human/Rat ERBB2 / HER2 ELISA Kit (Cell-Based ELISA) - LS-F2046 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate
Range 8.19-2000 pg/ml

Human ERBB2 / HER2 ELISA Kit (Sandwich ELISA) - LS-F77 from LifeSpan Bioscience

Category ELISA Kit
Prices $460.00, $840.00, $1,960.00
Sizes 1 plate, 2 plate, 5 plate
Sensitivity 8.19 pg/ml
Range 8.19-2000 pg/ml

Mouse/Human/Rat Phospho-ERBB2 / HER2 (Tyr1112) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1662 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 8.19-2000 pg/ml

Mouse/Human/Rat Phospho-ERBB2 / HER2 (Tyr1221, Tyr1222) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1526 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 8.19-2000 pg/ml

Mouse/Human/Rat Phospho-ERBB2 / HER2 (Tyr1248) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1527 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 8.19-2000 pg/ml

Mouse/Human/Rat Phospho-ERBB2 / HER2 (Tyr877) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1528 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 8.19-2000 pg/ml

Rat ERBB2 / HER2 ELISA Kit (Sandwich ELISA) - LS-F11388 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.312
Range 8.19-2000 pg/ml

Human ERBB2 / HER2 ELISA Kit (Sandwich ELISA) - LS-F11387 from LifeSpan Bioscience

Category ELISA Kit
Prices $530.00
Sizes 1 plate
Sensitivity 0.312
Range 8.19-2000 pg/ml

Rabbit anti-ErbB2 Antibody, Affinity Purified - PLA0123 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunohistochemistry</B><BR/>Rabbit Anti-ErbB2 Antibody, Affinity Purified: <B>Cat. No. PLA0123</B>: Detection of Human ErbB2 by Immunohistochemistry. Sample: FFPE section of Human breast carcinoma. Antibody: Affinity purified Rabbit Anti-ErbB2 (<B>Cat. No. PLA0123</B>) used at a dilution of 1:200 (1 μg/mL). Detection: DAB

Phosphotyrosine ERBB2 / Receptor Tyrosine-protein Kinase erbB-2 ELISA Kit - RAB0955 from Sigma-Aldrich

Category ELISA Kit
Prices $637.00
Sizes 1 kt

Human ErbB2 / HER2 ELISA Kit - RAB0173 from Sigma-Aldrich

Category ELISA Kit
Prices $423.50
Sizes 1 kt
<B>Standard Curve</B><BR/>: Typical Standard Curve for Human ErbB2 / HER2 ELISA Kit, <B>Cat. No. RAB0173</B>. The standard curve(s) displayed are for demonstration only. A standard curve must be run with each assay.

Human Total ErbB2/Her2 DuoSet IC ELISA - DYC1129-2 from R&D Systems

Category ELISA Kit
Prices $329.00, $649.00, $1,395.00
Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates), 1 pack (for 15 Plates)
Range 62.50 - 4,000 pg/mL

Human Total ErbB2/Her2 DuoSet IC, 5 Plate - DYC1129-5 from R&D Systems

Category ELISA Kit
Search more