ERBB2

Gene Symbol ERBB2
Entrez Gene 2064
Alt Symbol CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Species Human
Gene Type protein-coding
Description erb-b2 receptor tyrosine kinase 2
Other Description c-erb B2/neu protein|herstatin|human epidermal growth factor receptor 2|metastatic lymph node gene 19 protein|neuro/glioblastoma derived oncogene homolog|neuroblastoma/glioblastoma derived oncogene homolog|p185erbB2|proto-oncogene Neu|proto-oncogene c-ErbB-2|receptor tyrosine-protein kinase erbB-2|tyrosine kinase-type cell surface receptor HER2|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2|v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2|v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Swissprots B4DHN3 B2RZG3 Q9UMK4 X5D2V5 Q6LDV1 Q14256 P04626
Accessions AAA35809 AAA35978 AAA58637 AAC37531 AAD15229 AAF30295 AAO18082 BAE15959 BAE15960 CCA94568 CCQ77584 EAW60595 EAW60596 EAW60597 P04626 AB025286 AF177761 AAD56009 AK131568 AK295195 BAG58195 AK296908 BAG59464 AK300321 BAG62073 AK309029 AK313683 BC080193 BC110392 BC156755 AAI56756 BC167147 AAI67147 BI755753 BM678576 CN409735 DC346286 HM437238 ADN43069 HY033940 KJ534831 AHW56471 KJ534832 AHW56472 KJ534964 AHW56604 M11730 AAA75493 S57296 AAD14920 X03363 CAA27060 NM_001005862 NP_001005862 NM_001289936 NP_001276865 NM_001289937 NP_001276866 NM_001289938 NP_001276867 NM_004448 NP_004439 NR_110535
Function Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Subcellular Location Isoform 3: Cytoplasm. Nucleus.
Tissue Specificity Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. {ECO:0000269|PubMed:15380516}.
Top Pathways Proteoglycans in cancer, MicroRNAs in cancer, Central carbon metabolism in cancer, Adherens junction, Calcium signaling pathway

HER2/ErbB2 (D8F12) XP ® Rabbit mAb (Biotinylated) - 8609 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8F12
Western blot analysis of extracts from various cell lines using HER2/ErbB2 (D8F12) XP ® Rabbit mAb (Biotinylated).

Phospho-HER2/ErbB2 (Tyr1221/1222) Antibody - 2249 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from untreated SKBR3 and MCF-7 cells, untreated or treated with neuregulin (NRG), using Phospho-HER2/ErbB2 (Tyr1221/1222) Antibody (upper) and HER2/ErbB2 Antibody #2242 (lower).

Phospho-HER2/ErbB2 (Tyr1221/1222) (6B12) Rabbit mAb - 2243 from Cell Signaling Technology

Prices $109.00, $307.00, $719.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Monoclonal
Clone 6B12
Western blot analysis of extracts from cells expressing different activated tyrosine kinase proteins, using Phospho-HER2/ErbB2 (Tyr1221/1222) (6B12) Rabbit mAb (upper) or Phospho-Tyrosine mAb (P-Tyr-100) #9411 (lower). Phospho-HER2/ErbB2 (Tyr1221/1222) (6B12) Rabbit mAb specifically detects phosphorylated HER2/ErbB2 but not other phosphorylated tyrosine kinases.

Phospho-HER2/ErbB2 (Tyr877) Antibody - 2241 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from MCF-7 cells, untreated or treated with neuregulin (NRG), using Phospho-HER2/ErbB2 (Tyr877) Antibody (upper) and HER2/ErbB2 Antibody #2242 (lower).

Phospho-HER2/ErbB2 (Tyr1196) (D66B7) Rabbit mAb - 6942 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D66B7
Western blot analysis of extracts from T47D and MCF7 cells, untreated or treated with human neuregulin-1 #5218 (100 ng/ml, 5 min), using Phospho-HER2/ErbB2 (Tyr1196) (D66B7) Rabbit mAb (upper) and HER2/ErbB2 (29D8) Rabbit mAb #2165 (lower).

Phospho-HER2/ErbB2 (Tyr1248) Antibody - 2247 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of activated recombinant HER2/ErbB2 and HER1/EGFR tyrosine kinase proteins, using Phospho-HER2/ErbB2 (Tyr1248) (upper), EGF Receptor (D38B1) XP ® Rabbit mAb #4267 (middle) or HER2/ErbB2 (29D8) Rabbit mAb #2165 (lower). Phospho-HER2/ErbB2 (Tyr1248) specifically detects phosphorylated HER2/ErbB2 but not phosphorylated HER1/EGFR.

HER2/ErbB2 (D8F12) XP ® Rabbit mAb - 4290 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8F12
Western blot analysis of extracts from SK-BR-3 and MCF7 cells using HER2/ErbB2 (D8F12) XP ® Rabbit mAb.

HER2/ErbB2 (M45) Antibody - 3250 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of cell extracts from SK-BR-3 and MDA-MB-453 cells using HER2/ErbB2 (M45) Antibody.

HER2/ErbB2 (44E7) Mouse mAb - 2248 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 44E7
Western blot analysis of extracts from SK-BR-3 cells as well as COS cells mock transfected or transfected with Her2/ErbB2 using Her2/ErbB2 (44E7) Mouse mAb #2248.

HER2/ErbB2 Antibody - 2242 from Cell Signaling Technology

Prices $246.00, $596.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from MCF-7 and SKBR3 cells using HER2/ErbB2 Antibody.

HER2/ErbB2 (29D8) Rabbit mAb - 2165 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 29D8
Western blot analysis of cell extracts from various cell lines, using HER2/ErbB2 (29D8) Rabbit mAb.

Phospho-HER2/ErbB2 (Tyr1112) Antibody - 2245 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Neu (3B5) - sc-33684 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Neu phosphorylation in untreated (A,D), Neuregulin-1 treated (B,E) and Neuregulin-1 and lambda protein phosphatase (sc-200312A) treated (C,F) T-47D whole cell lysates. Antibodies tested include p-Neu (Tyr 1221/1222): sc-101694 (A,B,C) and Neu (3B5): sc-33684 (D,E,F).

Neu (A-2) - sc-393712 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Neu (A-2): sc-393712. Western blot analysis of Neu expression in SK-BR-3 (A) and MCF7 (B) whole cell lysates.

Neu (24D2) - sc-23864 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Neu (24D2) PE: sc-23864 PE. FCM analysis of T-47D cells. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2866.

Neu (C-12) - sc-374382 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Neu (C-12): sc-374382. Western blot analysis of Neu expression in SKBR-3 whole cell lysate.

Neu (C-14) - sc-31154 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Neu (C-14): sc-31154. Western blot analysis of Neu expression in SK-BR-3 whole cell lysate.

Neu (C-3) - sc-377344 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Neu (C-3): sc-377344. Western blot analysis of Neu expression in SK-BR-3 whole cell lysate.

Neu (C-18) - sc-284 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Neu (C-18): sc-284. Western blot analysis of Neu gp185 expression in SK-BR-3 whole cell lysate.

Neu (D-16) - sc-31153 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Neu (D-16): sc-31153. Western blot analysis of Neu expression in SK-BR-3 whole cell lysate.

Neu (H-200) - sc-134481 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Neu (F-11) - sc-7301 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Neu (F-11): sc-7301. Immunofluorescence staining of methanol-fixed NIH/3T3 cells transfected with Neu showing membrane staining.

Neu (CB11) - sc-52349 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl supernatant
Host Mouse
Clonality Monoclonal
Neu (CB11): sc-52349. Western blot analysis of Neu expression in MCF7 (A), SK-BR-3 (B) and T-47D (C) whole cell lysates.

Neu (9G6) - sc-08 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Neu (9G6): sc-08. Immunofluorescence staining of methanol-fixed SK-BR-3 cells showing membrane localization.

Neu (42) - sc-136294 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Neu (42): sc-136294. Immunofluorescence staining of A-431 cells showing cytoplasmic and membrane localization.
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