| Gene Symbol |
TCEB2
|
| Entrez Gene |
6923
|
| Alt Symbol |
ELOB, SIII
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
|
| Other Description |
RNA polymerase II transcription factor SIII p18 subunit|RNA polymerase II transcription factor SIII subunit B|SIII p18|elongin 18 kDa subunit|elongin, 18-kD subunit|elongin-B|transcription elongation factor B polypeptide 2
|
| Swissprots |
B7WPD3 Q15370
|
| Accessions |
AAC08452 EAW85472 EAW85473 EAW85474 EAW85475 EAW85476 Q15370 AI191983 BC013306 AAH13306 BC065000 AAH65000 BF967495 BG329435 BM553320 BM700019 BM921799 BU533433 DT217333 EU447012 ABZ92541 L42856 AAA75522 NM_007108 NP_009039 NM_207013 NP_996896
|
| Function |
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Renal cell carcinoma
|