Gene Symbol | TCEB2 |
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Entrez Gene | 6923 |
Alt Symbol | ELOB, SIII |
Species | Human |
Gene Type | protein-coding |
Description | transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) |
Other Description | RNA polymerase II transcription factor SIII p18 subunit|RNA polymerase II transcription factor SIII subunit B|SIII p18|elongin 18 kDa subunit|elongin, 18-kD subunit|elongin-B|transcription elongation factor B polypeptide 2 |
Swissprots | B7WPD3 Q15370 |
Accessions | AAC08452 EAW85472 EAW85473 EAW85474 EAW85475 EAW85476 Q15370 AI191983 BC013306 AAH13306 BC065000 AAH65000 BF967495 BG329435 BM553320 BM700019 BM921799 BU533433 DT217333 EU447012 ABZ92541 L42856 AAA75522 NM_007108 NP_009039 NM_207013 NP_996896 |
Function | SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). |
Subcellular Location | Nucleus {ECO:0000305}. |
Top Pathways | Ubiquitin mediated proteolysis, Renal cell carcinoma |
Elongin B CRISPR/Cas9 KO Plasmid (h) - sc-402154 from Santa Cruz Biotechnology
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Elongin B HDR Plasmid (h) - sc-402154-HDR from Santa Cruz Biotechnology
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Elongin B Double Nickase Plasmid (h) - sc-402154-NIC from Santa Cruz Biotechnology
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Elongin B Double Nickase Plasmid (h2) - sc-402154-NIC-2 from Santa Cruz Biotechnology
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Elongin B CRISPR Activation Plasmid (h) - sc-402154-ACT from Santa Cruz Biotechnology
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Elongin B CRISPR Activation Plasmid (h2) - sc-402154-ACT-2 from Santa Cruz Biotechnology
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Elongin B Lentiviral Activation Particles (h) - sc-402154-LAC from Santa Cruz Biotechnology
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Elongin B Lentiviral Activation Particles (h2) - sc-402154-LAC-2 from Santa Cruz Biotechnology
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Elongin B siRNA (h) - sc-35294 from Santa Cruz Biotechnology
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Elongin B shRNA Plasmid (h) - sc-35294-SH from Santa Cruz Biotechnology
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Elongin B shRNA (h) Lentiviral Particles - sc-35294-V from Santa Cruz Biotechnology
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TCEB2 RNAi - H00006923-R01 from Novus Biologicals
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MISSION® esiRNA - EHU150621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21132 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21132 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12148 from Sigma-Aldrich
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TCEB2 siRNA (Human) - CRH4745 from Cohesion Biosciences
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TCEB2 RNAi - H00006923-R02 from Novus Biologicals
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TCEB2 - MBS8219060 from MyBioSource
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Elongin B CRISPR/Cas9 KO Plasmid (h2) - sc-402154-KO-2 from Santa Cruz Biotechnology
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Elongin B HDR Plasmid (h2) - sc-402154-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human TCEB2 (NM_007108.3) - SHH424680 from Creative biogene
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Human TCEB2 siRNA - orb265247 from Biorbyt
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TCEB2 shRNA Plasmid (Human) - CHH4745 from Cohesion Biosciences
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TCEB2 miRNA 3'UTR clone - MiUTR3H-03628 from Creative biogene
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