| Gene Symbol | APOC3 |
|---|---|
| Entrez Gene | 345 |
| Alt Symbol | APOCIII, HALP2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | apolipoprotein C-III |
| Other Description | apo-CIII|apoC-III|apolipoprotein C3 |
| Swissprots | Q08E83 P02656 Q6Q786 |
| Accessions | AAB59372 AAB59515 AAQ91810 AAS68230 ACA05940 ACA05941 ACA05942 AJA40867 CAA25648 CAA26895 CAI23899 CDM21968 EAW67272 EAW67273 P02656 BC027977 AAH27977 BC121081 AAI21082 BC134419 AAI34420 DQ892044 ABM82970 DQ895238 ABM86164 M28613 AAA51760 M28614 AAA51761 V01513 CAA24757 X00567 CAA25233 X01388 CAA25644 NM_000040 NP_000031 |
| Function | Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. {ECO:0000303|PubMed:18201179, ECO:0000303|PubMed:22510806}. |
| Subcellular Location | Secreted {ECO:0000303|PubMed:18201179, ECO:0000303|PubMed:22510806}. |
| Tissue Specificity | Liver. {ECO:0000269|PubMed:6328445}. |
| Top Pathways | PPAR signaling pathway |