APOC3

Gene Symbol APOC3
Entrez Gene 345
Alt Symbol APOCIII, HALP2
Species Human
Gene Type protein-coding
Description apolipoprotein C-III
Other Description apo-CIII|apoC-III|apolipoprotein C3
Swissprots Q08E83 P02656 Q6Q786
Accessions AAB59372 AAB59515 AAQ91810 AAS68230 ACA05940 ACA05941 ACA05942 AJA40867 CAA25648 CAA26895 CAI23899 CDM21968 EAW67272 EAW67273 P02656 BC027977 AAH27977 BC121081 AAI21082 BC134419 AAI34420 DQ892044 ABM82970 DQ895238 ABM86164 M28613 AAA51760 M28614 AAA51761 V01513 CAA24757 X00567 CAA25233 X01388 CAA25644 NM_000040 NP_000031
Function Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. {ECO:0000303|PubMed:18201179, ECO:0000303|PubMed:22510806}.
Subcellular Location Secreted {ECO:0000303|PubMed:18201179, ECO:0000303|PubMed:22510806}.
Tissue Specificity Liver. {ECO:0000269|PubMed:6328445}.
Top Pathways PPAR signaling pathway

apoC-III (H-75) - sc-50377 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

apoC-III (V-20) - sc-23604 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Apolipoprotein CIII antibody [EP1372Y] - ab76305 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1372Y
Anti-Apolipoprotein CIII antibody [EP1372Y] (ab76305) at 1/2000 dilution + Human liver tissue lysate at 10 µgSecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Apolipoprotein CIII antibody [EPR1371(2)] - ab108205 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1371(2)
All lanes : Anti-Apolipoprotein CIII antibody [EPR1371(2)] (ab108205) at 1/1000 dilutionLane 1 : Human plasma Lane 2 : HDL cell lysatesLysates/proteins at 10 µg per lane.

Anti-Apolipoprotein CIII antibody - ab21032 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab21032 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab21032, 5µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Apolipoprotein CIII antibody - ab7619 from Abcam

Prices $384.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
IHC image of ab7619 staining in human normal liver formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol B. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab7619, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Apolipoprotein CIII antibody - ab84290 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of Apolipoprotein CIII staining in human liver carcinoma formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab84290, 10µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX

Anti-Apolipoprotein CIII antibody - ab124256 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab124256 at 5 µg/ml, staining Apolipoprotein CIII in Formalin-Fixed Human Liver by immunohistochemistry.

Anti-Apolipoprotein CIII antibody - ab77664 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Formalin fixed and paraffin embedded human hepatocarcinoma tissue stained with ab77664, at a 1/10 dilution, followed by treatment with a peroxidase conjugated secondary antibody and DAB staining.

Anti-Apolipoprotein CIII antibody (Biotin) - ab21024 from Abcam

Prices $378.00
Sizes 100 µl
Host Goat
Clonality Polyclonal
Sandwich ELISA, detecting Apolipoprotein CIII levels in Human or cynomolgus monkey serum, using ab21024 as detection antibody. Anti-human Apolipoprotein CIII polyclonal antibody (ab21032) was added to an ELISA plate and incubated overnight at 4°C. Blocking buffer was added and incubated for 1 hour at room temperature. 50 µl of serum or standard was added to each well and incubated for 2 hours at room temperature. After washing, 50 µl/well of detection antibody (ab21024 at 1 µg/ml) was added and incubated at room temperature 1 hour followed by 50 µl/well of Streptavidin-HRP (ab64269). After color development, the absorbance was read at 450nm.

Anti-Apolipoprotein CIII antibody (FITC) - ab27612 from Abcam

Prices $370.00
Sizes 100 µl
Host Goat
Clonality Polyclonal

Anti-Apolipoprotein CIII antibody (HRP) - ab27624 from Abcam

Prices $372.00
Sizes 100 µl
Host Goat
Clonality Polyclonal

Anti-Apolipoprotein CIII antibody (HRP) - ab31528 from Abcam

Prices $370.00
Sizes 250 µl
Host Goat
Clonality Polyclonal

Anti-Apolipoprotein CIII antibody - Aminoterminal end - ab55984 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-APOC3 / Apolipoprotein C III Antibody - LS-C20742 from LifeSpan Bioscience

Prices $395.00
Sizes 5 ml
Host Goat
Clonality Polyclonal

Anti-APOC3 / Apolipoprotein C III Antibody - LS-C20741 from LifeSpan Bioscience

Prices $395.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal

Anti-APOC3 / Apolipoprotein C III Antibody - LS-C47252 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-APOC3 / Apolipoprotein C III Antibody - LS-C69179 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-APOC3 / Apolipoprotein C III Antibody - LS-C69181 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-APOC3 / Apolipoprotein C III Antibody - LS-C85654 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal

Anti-APOC3 / Apolipoprotein C III Antibody - LS-C69182 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-APOC3 / Apolipoprotein C III Antibody (N-Terminus) - LS-C47120 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-APOC3 / Apolipoprotein C III Antibody - LS-C92147 from LifeSpan Bioscience

Prices $365.00
Sizes 1 ml
Host Goat
Clonality Polyclonal

Anti-APOC3 / Apolipoprotein C III Antibody (Biotin) - LS-C126860 from LifeSpan Bioscience

Prices $475.00
Sizes 500 µl
Host Goat
Clonality Polyclonal

Anti-APOC3 / Apolipoprotein C III Antibody (HRP) - LS-C126861 from LifeSpan Bioscience

Prices $575.00
Sizes 1 ml
Host Goat
Clonality Polyclonal
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