| Gene Symbol |
GAS2
|
| Entrez Gene |
2620
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
growth arrest-specific 2
|
| Other Description |
GAS-2|growth arrest-specific protein 2
|
| Swissprots |
Q7Z3X8 O43903 Q6ICV8 D3DQZ0 B2R9C8
|
| Accessions |
EAW68317 EAW68318 O43903 AI374985 AK313734 BAG36475 AU099094 BC005077 AAH05077 BC013326 AAH13326 BC040470 AAH40470 CR450285 CAG29281 DA345287 U95032 AAC52058 XM_011519971 XP_011518273 XM_011519972 XP_011518274 XM_011519973 XP_011518275 XM_011519974 XP_011518276 XM_011519975 XP_011518277 XM_011519976 XP_011518278 XM_011519977 XP_011518279 XM_011519978 XP_011518280 XM_011519979 XP_011518281 NM_001143830 NP_001137302 NM_005256 NP_005247 NM_177553 NP_808221
|
| Function |
May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth- arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.
|