Gene Symbol | GAS2 |
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Entrez Gene | 2620 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | growth arrest-specific 2 |
Other Description | GAS-2|growth arrest-specific protein 2 |
Swissprots | Q7Z3X8 O43903 Q6ICV8 D3DQZ0 B2R9C8 |
Accessions | EAW68317 EAW68318 O43903 AI374985 AK313734 BAG36475 AU099094 BC005077 AAH05077 BC013326 AAH13326 BC040470 AAH40470 CR450285 CAG29281 DA345287 U95032 AAC52058 XM_011519971 XP_011518273 XM_011519972 XP_011518274 XM_011519973 XP_011518275 XM_011519974 XP_011518276 XM_011519975 XP_011518277 XM_011519976 XP_011518278 XM_011519977 XP_011518279 XM_011519978 XP_011518280 XM_011519979 XP_011518281 NM_001143830 NP_001137302 NM_005256 NP_005247 NM_177553 NP_808221 |
Function | May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth- arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles (By similarity). {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen. |
Gas2 CRISPR/Cas9 KO Plasmid (h) - sc-418122 from Santa Cruz Biotechnology
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Gas2 HDR Plasmid (h) - sc-418122-HDR from Santa Cruz Biotechnology
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Gas2 Double Nickase Plasmid (h) - sc-418122-NIC from Santa Cruz Biotechnology
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Gas2 Double Nickase Plasmid (h2) - sc-418122-NIC-2 from Santa Cruz Biotechnology
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Gas2 CRISPR Activation Plasmid (h) - sc-418122-ACT from Santa Cruz Biotechnology
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Gas2 CRISPR Activation Plasmid (h2) - sc-418122-ACT-2 from Santa Cruz Biotechnology
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Gas2 Lentiviral Activation Particles (h) - sc-418122-LAC from Santa Cruz Biotechnology
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Gas2 Lentiviral Activation Particles (h2) - sc-418122-LAC-2 from Santa Cruz Biotechnology
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Gas2 siRNA (h) - sc-62368 from Santa Cruz Biotechnology
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Gas2 shRNA Plasmid (h) - sc-62368-SH from Santa Cruz Biotechnology
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Gas2 shRNA (h) Lentiviral Particles - sc-62368-V from Santa Cruz Biotechnology
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GAS2 RNAi - H00002620-R01 from Novus Biologicals
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GAS2 RNAi - H00002620-R02 from Novus Biologicals
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MISSION® esiRNA - EHU012781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9137 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9137 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07610 from Sigma-Aldrich
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GAS2 siRNA (Human) - CRH1736 from Cohesion Biosciences
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GAS2 - MBS8204609 from MyBioSource
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shRNA set against Human GAS2 (NM_005256.3) - SHH299413 from Creative biogene
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Human GAS2 siRNA - orb262238 from Biorbyt
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GAS2 shRNA Plasmid (Human) - CHH1736 from Cohesion Biosciences
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GAS2 miRNA 3'UTR clone - MiUTR4H-TG11279 from Creative biogene
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