| Gene Symbol |
AGBL1
|
| Entrez Gene |
123624
|
| Alt Symbol |
CCP4, FECD8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATP/GTP binding protein-like 1
|
| Other Description |
cytosolic carboxypeptidase 4
|
| Swissprots |
C9JHL5 A1A4X5 Q96MI9 A6NJH6
|
| Accessions |
EAX01983 EAX01984 Q96MI9 AK056872 BAB71299 BC128152 AAI28153 DA695799 DV080155 DV080218 DV080486 DV080541 DY655391 DY655510 XM_011521226 XP_011519528 XM_011521227 XP_011519529 XM_011521228 XP_011519530 XM_011521229 XP_011519531 XM_011521230 XP_011519532 XR_931750 XR_931751 NM_152336 NP_689549
|
| Function |
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. {ECO:0000250|UniProtKB:Q09M05}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:24094747}.
|
| Tissue Specificity |
Expressed in corneal endothelium. {ECO:0000269|PubMed:24094747}.
|