Gene Symbol | AGBL1 |
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Entrez Gene | 123624 |
Alt Symbol | CCP4, FECD8 |
Species | Human |
Gene Type | protein-coding |
Description | ATP/GTP binding protein-like 1 |
Other Description | cytosolic carboxypeptidase 4 |
Swissprots | C9JHL5 A1A4X5 Q96MI9 A6NJH6 |
Accessions | EAX01983 EAX01984 Q96MI9 AK056872 BAB71299 BC128152 AAI28153 DA695799 DV080155 DV080218 DV080486 DV080541 DY655391 DY655510 XM_011521226 XP_011519528 XM_011521227 XP_011519529 XM_011521228 XP_011519530 XM_011521229 XP_011519531 XM_011521230 XP_011519532 XR_931750 XR_931751 NM_152336 NP_689549 |
Function | Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. {ECO:0000250|UniProtKB:Q09M05}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:24094747}. |
Tissue Specificity | Expressed in corneal endothelium. {ECO:0000269|PubMed:24094747}. |
CCP4 CRISPR/Cas9 KO Plasmid (h) - sc-410529 from Santa Cruz Biotechnology
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CCP4 HDR Plasmid (h) - sc-410529-HDR from Santa Cruz Biotechnology
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CCP4 Double Nickase Plasmid (h) - sc-410529-NIC from Santa Cruz Biotechnology
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CCP4 Double Nickase Plasmid (h2) - sc-410529-NIC-2 from Santa Cruz Biotechnology
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CCP4 CRISPR Activation Plasmid (h) - sc-410529-ACT from Santa Cruz Biotechnology
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CCP4 CRISPR Activation Plasmid (h2) - sc-410529-ACT-2 from Santa Cruz Biotechnology
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CCP4 Lentiviral Activation Particles (h) - sc-410529-LAC from Santa Cruz Biotechnology
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CCP4 Lentiviral Activation Particles (h2) - sc-410529-LAC-2 from Santa Cruz Biotechnology
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CCP4 siRNA (h) - sc-90208 from Santa Cruz Biotechnology
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CCP4 shRNA Plasmid (h) - sc-90208-SH from Santa Cruz Biotechnology
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CCP4 shRNA (h) Lentiviral Particles - sc-90208-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU036351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2936 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2936 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00529 from Sigma-Aldrich
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AGBL1 siRNA (Human) - CRJ4735 from Cohesion Biosciences
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AGBL1 - MBS8211448 from MyBioSource
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AGBL1 shRNA Plasmid (Human) - CHJ4735 from Cohesion Biosciences
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