Smad2

Gene Symbol Smad2
Entrez Gene 17126
Alt Symbol 7120426M23Rik, Madh2, Madr2, Smad-2, mMad2
Species Mouse
Gene Type protein-coding
Description SMAD family member 2
Other Description MAD homolog 2|Smad 2|mad-related protein 2|mothers against DPP homolog 2|mothers against decapentaplegic homolog 2
Swissprots Q6GU18 Q9D8P6 Q6VP00 Q62432
Accessions EDL09484 EDL09485 Q62432 AF005743 AAB62269 AK007817 BAB25282 AK031111 AK078612 AK088249 BAC40236 AV232667 AY334552 AAR00933 BC021342 AAH21342 BC058713 BC089184 AAH89184 BM248478 BU058005 CN456711 U60530 AAB03612 XM_006525699 XP_006525762 XM_011246854 XP_011245156 NM_001252481 NP_001239410 NM_010754 NP_034884
Function Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Cytoplasmic and nuclear in the absence of TGF- beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (By similarity). {ECO:0000250}.
Top Pathways Chagas disease (American trypanosomiasis), Inflammatory bowel disease (IBD), Signaling pathways regulating pluripotency of stem cells, Proteoglycans in cancer, Hippo signaling pathway

Mothers against decapentaplegic homolog 2, Smad2, Mouse, ELISA Kit - E2184m from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t

Mothers Against Decapentaplegic Homolog 2, ELISA Kit - MBS063469 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Mothers Against Decapentaplegic Homolog 2 (Smad2) - SEC124Mu from Cloud-clone

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 24.6pg/mL.
Range 62.5-4000pg/mL The standard curve concentrations used for the ELISA's were 4000pg/mL, 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL

Mouse Smad2 ELISA Kit - abx154692 from Abbexa

Category ELISA Kit
Sensitivity 24.6 pg/ml
Range 62.5 pg/ml - 4000 pg/ml

Mothers Against Decapentaplegic Homolog 2 (Smad2), Mouse, ELISA Kit - DL-Smad2-Mu from ARP American Research Products

Category ELISA Kit
Prices $685.00
Sizes 96 t
Range 62.5-4,000 pg/mL

Mouse Smad2 ELISA Kit - orb369358 from Biorbyt

Category ELISA Kit
Prices $561.00, $638.00
Sizes 48 test, 96 test
Range Detection Range: 62.5-4000pg/mL Detection low threshold: 24.6pg/mL

Mouse Smad2 ELISA Kit - abx576067 from Abbexa

Category ELISA Kit
Sensitivity 24.6 pg/ml
Range 62.5 pg/ml - 4000 pg/ml

Mouse Smad2 ELISA Kit - E060462 from Biobool

Category ELISA Kit

SMAD2 ELISA Kit (Mouse) (OKEH03472) - OKEH03472 from Aviva Systems Biology

Category ELISA Kit
Prices $425.00
Sizes 96 wells
Sensitivity 0.156 ng/mL
Range 0.312 - 20 ng/mL

Mouse Mothers against decapentaplegic homolog 2 ELISA Kit - EK4368 from Signalway Antibody

Category ELISA Kit
Prices $599.00
Sizes 1x96t
Range 0.625-40 ng/mL

Mothers against decapentaplegic homolog 2, ELISA Kit - MBS9428194 from MyBioSource

Category ELISA Kit
Prices $555.00
Sizes 96 tests
Range 0.31 ng/mL-20.0 ng/mL

Mothers against decapentaplegic homolog 2, ELISA Kit - MBS2881020 from MyBioSource

Category ELISA Kit
Prices $380.00, $500.00, $2,170.00, $3,840.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mothers Against Decapentaplegic Homolog 2 (Smad2), ELISA Kit - MBS452472 from MyBioSource

Category ELISA Kit
Prices $425.00, $560.00, $2,480.00, $4,820.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 24.6pg/mL
Range 62.5-4000pg/mL
Search more