Smad2

Gene Symbol Smad2
Entrez Gene 17126
Alt Symbol 7120426M23Rik, Madh2, Madr2, Smad-2, mMad2
Species Mouse
Gene Type protein-coding
Description SMAD family member 2
Other Description MAD homolog 2|Smad 2|mad-related protein 2|mothers against DPP homolog 2|mothers against decapentaplegic homolog 2
Swissprots Q6GU18 Q9D8P6 Q6VP00 Q62432
Accessions EDL09484 EDL09485 Q62432 AF005743 AAB62269 AK007817 BAB25282 AK031111 AK078612 AK088249 BAC40236 AV232667 AY334552 AAR00933 BC021342 AAH21342 BC058713 BC089184 AAH89184 BM248478 BU058005 CN456711 U60530 AAB03612 XM_006525699 XP_006525762 XM_011246854 XP_011245156 NM_001252481 NP_001239410 NM_010754 NP_034884
Function Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Cytoplasmic and nuclear in the absence of TGF- beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (By similarity). {ECO:0000250}.
Top Pathways Chagas disease (American trypanosomiasis), Inflammatory bowel disease (IBD), Signaling pathways regulating pluripotency of stem cells, Proteoglycans in cancer, Hippo signaling pathway

Mouse Smad2 protein (GST Tag) - orb139670 from Biorbyt

Category Protein
Prices $323.00, $646.00
Sizes 20 μg, 100 μg
Source Baculovirus-Insect Cells
Species Mouse
SDS-PAGE analysis of mouse Smad2 protein (GST Tag)

Mouse Smad2 Protein - abx068069 from Abbexa

Category Protein
Source E.coli
Species Mouse

Mothers Against Decapentaplegic Homolog 2 (Smad2), Mouse - 20-8367 from ARP American Research Products

Category Protein
Prices $449.00
Sizes 50 µg
Source E.coli
Species Mouse

Mouse Smad2 Protein (His & GST Tag) - 50727-M20B-100 from Sino Biological

Category Protein
Prices $348.00, $348.00
Sizes 20 µg, 100 µg
Source Baculovirus-Insect Cells
Species Mouse

Recombinant Mothers Against Decapentaplegic Homolog 2 (Smad2) - RPC124Mu01 from Cloud-clone

Category Protein
Source E.coli
Species Mouse

Recombinant Mothers Against Decapentaplegic Homolog 2 (Smad2) - RPC124Mu02 from Cloud-clone

Category Protein
Source E.coli
Species Mouse

Recombinant Mouse Mothers against decapentaplegic homolog 2(Smad2) - CSB-YP733826MO CSB-EP733826MO CSB-BP733826MO CSB-MP733826MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Mothers Against Decapentaplegic Homolog 2 (Smad2) - RPU142804 from Biomatik

Category Protein
Prices $209.00, $418.00, $627.00
Sizes 10 µg, 50 µg, 100 µg
Source E.coli
Species Mouse

Recombinant Mouse Smad2 Protein (His & GST tag) - PKSM040517 from Elabscience

Category Protein
Source Baculoviru
Species Mouse

Mouse-Smad2-Blocking-Peptide-Center - BP21006a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg
Species Mouse

Recombinant Mothers Against Decapentaplegic Homolog 2 (Smad2) - RPU42804 from Biomatik

Category Protein
Prices $167.00, $342.00, $523.00, $653.60
Sizes 10 µg, 50 µg, 100 µg, 200 µg
Source E.coli
Species Mouse

SMAD2 Recombinant Protein (OPCD07062) - OPCD07062 from Aviva Systems Biology

Category Protein
Source E.coli
Species Mouse

Mouse Smad2 Protein (His & GST Tag) - 50727-M20B from ABclonal

Category Protein
Prices $138.00, $348.00
Sizes 20 µg, 100 µg
Source Baculovirus-Insect Cells
Species Mouse

Mothers against decapentaplegic homolog 2 (Smad2), Recombinant Protein - MBS1364321 from MyBioSource

Category Protein
Prices $1,250.00, $1,250.00, $1,470.00, $1,470.00, $2,035.00, $2,035.00, $2,500.00, $2,500.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

Mothers Against Decapentaplegic Homolog 2 (Smad2), Recombinant Protein - MBS2009454 from MyBioSource

Category Protein
Prices $170.00, $345.00, $535.00
Sizes 10 µg, 50 µg, 100 µg
Source Prokaryotic expression
Species Mouse

Smad2, Recombinant Protein - MBS2546819 from MyBioSource

Category Protein
Prices $375.00, $905.00
Sizes 20 µg, 100 µg
Source Baculovirus-Insect Cells
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