| Gene Symbol | Smad2 |
|---|---|
| Entrez Gene | 17126 |
| Alt Symbol | 7120426M23Rik, Madh2, Madr2, Smad-2, mMad2 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | SMAD family member 2 |
| Other Description | MAD homolog 2|Smad 2|mad-related protein 2|mothers against DPP homolog 2|mothers against decapentaplegic homolog 2 |
| Swissprots | Q6GU18 Q9D8P6 Q6VP00 Q62432 |
| Accessions | EDL09484 EDL09485 Q62432 AF005743 AAB62269 AK007817 BAB25282 AK031111 AK078612 AK088249 BAC40236 AV232667 AY334552 AAR00933 BC021342 AAH21342 BC058713 BC089184 AAH89184 BM248478 BU058005 CN456711 U60530 AAB03612 XM_006525699 XP_006525762 XM_011246854 XP_011245156 NM_001252481 NP_001239410 NM_010754 NP_034884 |
| Function | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Cytoplasmic and nuclear in the absence of TGF- beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (By similarity). {ECO:0000250}. |
| Top Pathways | Chagas disease (American trypanosomiasis), Inflammatory bowel disease (IBD), Signaling pathways regulating pluripotency of stem cells, Proteoglycans in cancer, Hippo signaling pathway |