| Gene Symbol | FZR1 |
|---|---|
| Entrez Gene | 51343 |
| Alt Symbol | CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | fizzy/cell division cycle 20 related 1 (Drosophila) |
| Other Description | CDC20-like 1b|CDC20-like protein 1|cdh1/Hct1 homolog|fizzy-related protein homolog |
| Swissprots | Q9UI96 Q9ULH8 Q9UM11 Q9UM10 Q86U66 Q9Y2T8 O75869 Q96NW8 Q9UNQ1 |
| Accessions | AAC62835 AAC62836 EAW69313 EAW69314 EAW69315 Q9UM11 AB013462 BAA86954 AB013463 BAA86955 AB033068 BAA86556 AF080397 AAF20266 AF083810 AAD52030 AF102507 AAD26623 AF102508 AAD26624 AF433157 AAL28117 BC013413 AAH13413 BC111760 BT007115 AAP35779 DB462260 DQ890739 ABM81665 HQ448330 ADQ32810 XM_005259573 XP_005259630 XM_011528053 XP_011526355 XR_936186 NM_001136197 NP_001129669 NM_001136198 NP_001129670 NM_016263 NP_057347 |
| Function | Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. {ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:9734353}. |
| Subcellular Location | Isoform 2: Nucleus. |
| Tissue Specificity | Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines whereas isoform 3 is expressed only at low levels in these tissues. {ECO:0000269|PubMed:12797865}. |
| Top Pathways | Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation |