FZR1

Gene Symbol	FZR1
Entrez Gene	51343
Alt Symbol	CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1
Species	Human
Gene Type	protein-coding
Description	fizzy/cell division cycle 20 related 1 (Drosophila)
Other Description	CDC20-like 1b|CDC20-like protein 1|cdh1/Hct1 homolog|fizzy-related protein homolog
Swissprots	Q9UI96 Q9ULH8 Q9UM11 Q9UM10 Q86U66 Q9Y2T8 O75869 Q96NW8 Q9UNQ1
Accessions	AAC62835 AAC62836 EAW69313 EAW69314 EAW69315 Q9UM11 AB013462 BAA86954 AB013463 BAA86955 AB033068 BAA86556 AF080397 AAF20266 AF083810 AAD52030 AF102507 AAD26623 AF102508 AAD26624 AF433157 AAL28117 BC013413 AAH13413 BC111760 BT007115 AAP35779 DB462260 DQ890739 ABM81665 HQ448330 ADQ32810 XM_005259573 XP_005259630 XM_011528053 XP_011526355 XR_936186 NM_001136197 NP_001129669 NM_001136198 NP_001129670 NM_016263 NP_057347
Function	Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. {ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:9734353}.
Subcellular Location	Isoform 2: Nucleus.
Tissue Specificity	Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines whereas isoform 3 is expressed only at low levels in these tissues. {ECO:0000269|PubMed:12797865}.
Top Pathways	Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FZR1 protein fragment - ab153347 from Abcam Category Protein Source Wheat germ Species Human

FZR1 Antibody Blocking Peptide - LS-E6318 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FZR1 Antibody Blocking Peptide - LS-E18460 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FZR1 Antibody Blocking Peptide - LS-E18461 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FZR1/CDH1 Protein - H00051343-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FZR1/CDH1 Partial Recombinant Protein - H00051343-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

FZR1-Antibody-N-term-Blocking-Peptide - BP19009a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human FZR1 protein - orb246659 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Fzr1 Blocking Peptide - 33R-8121 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FZR1 Blocking Peptide - 33R-8839 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FZR1 / CDH1 - H00051343-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

FZR1 / CDH1 - H00051343-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FZR1 / CDH1 - H00051343-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FZR1 / CDH1 - H00051343-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FZR1 / CDH1 - H00051343-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FZR1 fusion protein - ag9201 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Fizzy-related protein homolog(FZR1) - CSB-YP892473HU CSB-BP892473HU CSB-MP892473HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Fizzy-related protein homolog - CSB-EP892473HU from Cusabio Category Protein Source E.coli Species Human

FZR1 / CDH1 (transcript variant 2) - TP301413 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

FZR1/CDH1 Recombinant Protein Antigen - NBP1-91774PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

FZR1 Peptide, Human - M34GP05994H from Creative Peptides Category Peptide Source Synthetic. Species Human

FZR1 Recombinant Protein (OPCA02549) - OPCA02549 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Fizzy-related protein homolog, Recombinant Protein - MBS1437931 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $1,180.00, $1,280.00, $1,500.00, $1,500.00, $2,105.00, $2,570.00, $2,570.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Recombinant human Fizzy-related protein homolog - AP71618 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Fizzy-related protein homolog, Recombinant Protein - MBS9421480 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Human

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