Gene Symbol |
TRAFD1
|
Entrez Gene |
10906
|
Alt Symbol |
FLN29
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
TRAF-type zinc finger domain containing 1
|
Other Description |
FLN29 gene product|TRAF-type zinc finger domain-containing protein 1
|
Swissprots |
O14545 A8K5L6 B4DI89
|
Accessions |
CCQ43370 EAW97995 EAW97996 EAW97997 O14545 AB007447 BAA22541 AK122620 AK291331 BAF84020 AK295474 BAG58401 AK309916 AK312601 BC003553 AAH03553 BG828961 CA314188 DQ892530 ABM83456 DQ895741 ABM86667 NM_001143906 NP_001137378 NM_006700 NP_006691
|
Function |
Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250}.
|