LEPR

Gene Symbol	LEPR
Entrez Gene	3953
Alt Symbol	CD295, LEP-R, LEPRD, OB-R, OBR
Species	Human
Gene Type	protein-coding
Description	leptin receptor
Other Description	OB receptor|huB219
Swissprots	Q13592 Q13593 P48357 Q92921 Q92920 Q92919 Q13594
Accessions	AAB09673 AGB14642 CAH25983 P48357 AA813024 AI436180 AK001042 AK290208 BAF82897 AW302522 BC031086 AAH31086 BC035120 BC131779 AAI31780 BC160009 AAI60009 BX475249 U43168 AAA93015 U50748 AAC23650 U52912 AAC50509 U52913 AAC50510 U52914 AAC50511 U66495 AAB07495 U66496 AAB07496 U66497 AAB07497 NM_001003679 NP_001003679 NM_001003680 NP_001003680 NM_001198687 NP_001185616 NM_001198688 NP_001185617 NM_001198689 NP_001185618 NM_002303 NP_002294
Function	Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity). {ECO:0000250}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Leptin Receptor protein fragment - ab155615 from Abcam Category Protein Prices $410.00 Sizes 100 µg Source HEK 293 cells Species Human

Human Leptin Receptor peptide - ab50450 from Abcam Category Peptide Species Human

Human Leptin Receptor protein fragment - ab114278 from Abcam Category Protein Source Wheat germ Species Human

Leptin Receptor peptide - ab5837 from Abcam Category Peptide

LEPR-Antibody-C-term-Blocking-Peptide - BP17169b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Leptin Receptor blocking peptide - GTX89338-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog

Recombinant Mouse Leptin R Fc Chimera - 497-LR-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Mouse Leptin R Fc Chimera, CF - 497-LR-100/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human Leptin R Fc Chimera - 389-LR-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human Leptin R Fc Chimera, CF - 389-LR-100/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Leptin Receptor Protein (OPPA00767) - OPPA00767 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Leptin Receptor Protein (OPPA00768) - OPPA00768 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human Leptin Binding Domain protein - orb80512 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

Human Leptin Receptor His tag protein - orb83067 from Biorbyt Category Protein Prices $434.00, $612.00 Sizes 100 μg, 200 μg Source Human Species Human

Leptin Receptor Precursor peptide - orb70805 from Biorbyt Category Peptide Prices $374.00 Sizes 5 mg

CD295 Blocking Peptide - abx062871 from Abbexa Category Peptide Species Human

Human Leptin Receptor Protein - abx067745 from Abbexa Category Protein Source E.coli Species Human

Leptin Receptor Peptide - AC21-0932-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CD295 / Leptin Receptor - H00003953-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD295 / Leptin Receptor - H00003953-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD295 / Leptin Receptor - H00003953-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CD295 / Leptin Receptor Control Peptide - SP5132CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

Leptin Receptor (LEPR), Human - 20-6225 from ARP American Research Products Category Protein Prices $369.00 Sizes 50 µg Source E.coli Species Human

Leptin Receptor Peptide - 45-084P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

LEPR Recombinant Protein - 96-513 from ProSci Category Protein Prices $425.00 Sizes 100 µg Source HEK293 cells Species Human

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