LEPR
| Gene Symbol | LEPR |
|---|---|
| Entrez Gene | 3953 |
| Alt Symbol | CD295, LEP-R, LEPRD, OB-R, OBR |
| Species | Human |
| Gene Type | protein-coding |
| Description | leptin receptor |
| Other Description | OB receptor|huB219 |
| Swissprots | Q13592 Q13593 P48357 Q92921 Q92920 Q92919 Q13594 |
| Accessions | AAB09673 AGB14642 CAH25983 P48357 AA813024 AI436180 AK001042 AK290208 BAF82897 AW302522 BC031086 AAH31086 BC035120 BC131779 AAI31780 BC160009 AAI60009 BX475249 U43168 AAA93015 U50748 AAC23650 U52912 AAC50509 U52913 AAC50510 U52914 AAC50511 U66495 AAB07495 U66496 AAB07496 U66497 AAB07497 NM_001003679 NP_001003679 NM_001003680 NP_001003680 NM_001198687 NP_001185616 NM_001198688 NP_001185617 NM_001198689 NP_001185618 NM_002303 NP_002294 |
| Function | Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway |
Ob-R CRISPR/Cas9 KO Plasmid (h) - sc-400315 from Santa Cruz Biotechnology
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Ob-R HDR Plasmid (h) - sc-400315-HDR from Santa Cruz Biotechnology
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Ob-R Double Nickase Plasmid (h) - sc-400315-NIC from Santa Cruz Biotechnology
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Ob-R Double Nickase Plasmid (h2) - sc-400315-NIC-2 from Santa Cruz Biotechnology
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Ob-R CRISPR Activation Plasmid (h) - sc-400315-ACT from Santa Cruz Biotechnology
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Ob-R CRISPR Activation Plasmid (h2) - sc-400315-ACT-2 from Santa Cruz Biotechnology
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Ob-R Lentiviral Activation Particles (h) - sc-400315-LAC from Santa Cruz Biotechnology
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Ob-R Lentiviral Activation Particles (h2) - sc-400315-LAC-2 from Santa Cruz Biotechnology
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Ob-R siRNA (h) - sc-36115 from Santa Cruz Biotechnology
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Ob-R shRNA Plasmid (h) - sc-36115-SH from Santa Cruz Biotechnology
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Ob-R shRNA (h) Lentiviral Particles - sc-36115-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU094411 from Sigma-Aldrich
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MISSION® esiRNA - EHU087771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11648 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11648 from Sigma-Aldrich
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LEPR siRNA (Human) - CRH2676 from Cohesion Biosciences
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Leptin R RNAi - H00003953-R04 from Novus Biologicals
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Leptin R RNAi - H00003953-R05 from Novus Biologicals
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Ob-R CRISPR/Cas9 KO Plasmid (h2) - sc-400315-KO-2 from Santa Cruz Biotechnology
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Ob-R HDR Plasmid (h2) - sc-400315-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human Lepr (NM_002303.5) - SHH329619 from Creative biogene
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Human LEPR siRNA - orb263178 from Biorbyt
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LEPR shRNA Plasmid (Human) - CHH2676 from Cohesion Biosciences
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LEPR miRNA 3'UTR clone - MiUTR3H-03798 from Creative biogene
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