CENPU

Gene Symbol CENPU
Entrez Gene 79682
Alt Symbol CENP50, CENPU50, KLIP1, MLF1IP, PBIP1
Species Human
Gene Type protein-coding
Description centromere protein U
Other Description KSHV latent nuclear antigen interacting protein 1|KSHV latent nuclear antigen-interacting protein 1|MLF1 interacting protein|MLF1-interacting protein|centromere protein of 50 kDa|interphase centromere complex protein 24|polo-box-interacting protein 1
Swissprots Q32Q71 A2RRD9 Q71F23 Q9H5G1 Q09GN2
Accessions EAX04666 Q71F23 AA761728 AF469667 AAQ05290 AF516710 AAQ08228 AK027121 BAB15665 AK292297 BAF84986 AW440254 BC031520 AAH31520 BC067802 BC107744 AAI07745 BC131556 AAI31557 BC141854 AAI41855 BG031878 BX355581 CR457376 CAG33657 DQ907910 ABI49142 DQ907911 ABI49143 XM_005263218 XP_005263275 NM_024629 NP_078905 NR_104593
Function Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}.
Subcellular Location Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates.
Tissue Specificity Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:15116101, ECO:0000269|PubMed:15893739}.

MLF1IP (C-14) - sc-50101 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-MLF1 Interacting Protein/PBIP1 antibody - C-terminal - ab173218 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MLF1 Interacting Protein/PBIP1 antibody - C-terminal (ab173218) at 1/100 dilution + WiDr cell line lysate at 35 µg

Anti-CENPU / MLF1IP Antibody (C-Terminus) IHC-plus™ - LS-B10612 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CENPU / MLF1IP antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CENPU / MLF1IP Antibody (N-Terminus) IHC-plus™ - LS-B10613 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CENPU / MLF1IP antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CENPU / MLF1IP Antibody (aa291-319) - LS-C329832 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CENPU / MLF1IP Antibody (aa80-129) - LS-C187229 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Placenta . MLF1IP antibody dilution 1.0 ug/ml.

Anti-CENPU / MLF1IP Antibody (aa214-263) - LS-C187228 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human 721_B . MLF1IP antibody dilution 1.0 ug/ml.

Anti-CENPU / MLF1IP Antibody IHC-plus™ - LS-B9930 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-CENPU / MLF1IP Antibody (phospho-Thr78) IHC-plus™ - LS-B71 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MLF1IP / PBIP1 antibody IHC of human colon adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B71 concentration 20 ug/ml.

Anti-CENPU / MLF1IP Antibody (phospho-Thr78) IHC-plus™ - LS-B211 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MLF1IP / PBIP1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B211 concentration 10 ug/ml.

Anti-CENPU / MLF1IP Antibody (aa291-319, AP) - LS-C263223 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CENPU / MLF1IP Antibody (aa291-319, Biotin) - LS-C263222 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CENPU / MLF1IP Antibody (aa291-319, FITC) - LS-C263225 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CENPU / MLF1IP Antibody (aa291-319, Azide-free, HRP) - LS-C263226 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CENPU / MLF1IP Antibody (aa291-319, PE) - LS-C263227 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CENPU / MLF1IP Antibody (aa291-319) - LS-C158151 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MLF1IP Antibody western blot of WiDr cell line lysates (35 ug/lane). The MLF1IP antibody detected the MLF1IP protein (arrow).

Anti-CENPU / MLF1IP Antibody (aa291-319, APC) - LS-C263224 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

MLF1 Interacting Protein [p Thr78] Antibody - NBP1-77938 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

MLF1 Interacting Protein [p Thr78] Antibody - NBP1-02440 from Novus Biologicals

Prices $329.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

MLF1 Interacting Protein Antibody - NBP1-85689 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: MLF1 Interacting Protein Antibody [NBP1-85689] - Staining of human cell line U-2 OS shows positivity in nucleus, cytoplasm and centrosome.

MLF1 Interacting Protein Antibody - NB110-85541 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: MLF1 Interacting Protein Antibody [NB110-85541] - Analysis of endogenous MLF1IP protein (a tier of four modified protein bands indicated by the arrowheads) in lysates of Hela cells (- lane). Cells treated with MLF1IP / PBIP1 shRNA (+ lane) show no staining. The identities of the higher and lower molecular weight bands are unknown. Primary antibody was used at 1:1,000.

MLF1 Interacting Protein Antibody - bs-5752R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit

MLF1 Interacting Protein(Thr78) Antibody - bs-5753R from Bioss

Prices $289.00
Sizes 100 µl
Host Rabbit

Anti-CENPU antibody produced in rabbit - SAB4301005 from Sigma-Aldrich

Prices $230.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MLF1IP antibody produced in rabbit - HPA022048 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MLF1IP: <B>Cat. No. HPA022048</B>: Immunohistochemical staining of human cerebellum shows strong cytoplasmic and nuclear positivity in Purkinje cells.
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