CENPU

Gene Symbol CENPU
Entrez Gene 79682
Alt Symbol CENP50, CENPU50, KLIP1, MLF1IP, PBIP1
Species Human
Gene Type protein-coding
Description centromere protein U
Other Description KSHV latent nuclear antigen interacting protein 1|KSHV latent nuclear antigen-interacting protein 1|MLF1 interacting protein|MLF1-interacting protein|centromere protein of 50 kDa|interphase centromere complex protein 24|polo-box-interacting protein 1
Swissprots Q32Q71 A2RRD9 Q71F23 Q9H5G1 Q09GN2
Accessions EAX04666 Q71F23 AA761728 AF469667 AAQ05290 AF516710 AAQ08228 AK027121 BAB15665 AK292297 BAF84986 AW440254 BC031520 AAH31520 BC067802 BC107744 AAI07745 BC131556 AAI31557 BC141854 AAI41855 BG031878 BX355581 CR457376 CAG33657 DQ907910 ABI49142 DQ907911 ABI49143 XM_005263218 XP_005263275 NM_024629 NP_078905 NR_104593
Function Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}.
Subcellular Location Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates.
Tissue Specificity Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:15116101, ECO:0000269|PubMed:15893739}.

MLF1IP CRISPR/Cas9 KO Plasmid (h) - sc-413208 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLF1IP HDR Plasmid (h) - sc-413208-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLF1IP Double Nickase Plasmid (h) - sc-413208-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLF1IP Double Nickase Plasmid (h2) - sc-413208-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLF1IP CRISPR Activation Plasmid (h) - sc-413208-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLF1IP CRISPR Activation Plasmid (h2) - sc-413208-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLF1IP Lentiviral Activation Particles (h) - sc-413208-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLF1IP Lentiviral Activation Particles (h2) - sc-413208-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLF1IP siRNA (h) - sc-61057 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MLF1IP shRNA Plasmid (h) - sc-61057-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MLF1IP shRNA (h) Lentiviral Particles - sc-61057-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU021731 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14393 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14393 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08595 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08595

CENPU siRNA (Human) - CRJ2483 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CENPU - MBS8238434 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MLF1IP (NM_024629.3) - SHH342440 from Creative biogene

Category siRNA
Species Reactivities Human

CENPU shRNA Plasmid (Human) - CHJ2483 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MLF1IP miRNA 3'UTR clone - MiUTR3H-11943 from Creative biogene

Species Reactivities Human
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