| Gene Symbol | CASK |
|---|---|
| Entrez Gene | 8573 |
| Alt Symbol | CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium/calmodulin-dependent serine protein kinase (MAGUK family) |
| Other Description | calcium/calmodulin-dependent serin protein kinase|calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase|hCASK|peripheral plasma membrane protein CASK|protein lin-2 homolog|trinucleotide repeat containing 8 |
| Swissprots | Q9BYH6 Q9NYB3 Q66T42 Q5VT18 B7ZKY0 Q9NYB2 Q5VT16 Q59HA0 O43215 Q5VT19 A6NES1 Q5VT17 O14936 Q17RI4 |
| Accessions | EAW59390 EAW59391 EAW59392 EAW59393 O14936 AB039327 BAB12252 AB208859 BAD92096 AF032119 AAB88125 AF035582 AAB88198 AF262404 AAF72666 AF262405 AAF72667 AK025872 AK056476 AK313399 AY705392 AAU10527 BC029936 BC035990 BC117311 AAI17312 BC143454 AAI43455 BC143456 AAI43457 DN993605 HQ258518 ADR83272 LN607837 CEF49524 XM_005272686 XP_005272743 XM_006724566 XP_006724629 XM_011543993 XP_011542295 XM_011543994 XP_011542296 XM_011543995 XP_011542297 XM_011543996 XP_011542298 XM_011543997 XP_011542299 NM_001126054 NP_001119526 NM_001126055 NP_001119527 NM_003688 NP_003679 |
| Function | Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. |
| Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver. {ECO:0000269|PubMed:11003712}. |
| Top Pathways | Tight junction |
CASK CRISPR/Cas9 KO Plasmid (h) - sc-401742 from Santa Cruz Biotechnology
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CASK HDR Plasmid (h) - sc-401742-HDR from Santa Cruz Biotechnology
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CASK Double Nickase Plasmid (h) - sc-401742-NIC from Santa Cruz Biotechnology
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CASK Double Nickase Plasmid (h2) - sc-401742-NIC-2 from Santa Cruz Biotechnology
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CASK CRISPR Activation Plasmid (h) - sc-401742-ACT from Santa Cruz Biotechnology
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CASK CRISPR Activation Plasmid (h2) - sc-401742-ACT-2 from Santa Cruz Biotechnology
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CASK Lentiviral Activation Particles (h) - sc-401742-LAC from Santa Cruz Biotechnology
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CASK Lentiviral Activation Particles (h2) - sc-401742-LAC-2 from Santa Cruz Biotechnology
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CASK siRNA (h) - sc-29920 from Santa Cruz Biotechnology
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CASK shRNA Plasmid (h) - sc-29920-SH from Santa Cruz Biotechnology
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CASK shRNA (h) Lentiviral Particles - sc-29920-V from Santa Cruz Biotechnology
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CASK RNAi - H00008573-R02 from Novus Biologicals
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MISSION® esiRNA - EHU074951 from Sigma-Aldrich
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MISSION® siRNA - SIHK0280 from Sigma-Aldrich
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MISSION® siRNA - SIHK0279 from Sigma-Aldrich
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MISSION® siRNA - SIHK0281 from Sigma-Aldrich
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MISSION® siRNA - SIHK0278 from Sigma-Aldrich
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MISSION® siRNA - SIHK0277 from Sigma-Aldrich
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MISSION® siRNA - SIHK0276 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2171 from Sigma-Aldrich
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CASK siRNA (Human) - CRH5640 from Cohesion Biosciences
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CASK - MBS8221924 from MyBioSource
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shRNA set against Human Cask (NM_003688.3) - SHH254889 from Creative biogene
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Human CASK siRNA - orb266142 from Biorbyt
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