CASK

Gene Symbol CASK
Entrez Gene 8573
Alt Symbol CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8
Species Human
Gene Type protein-coding
Description calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Other Description calcium/calmodulin-dependent serin protein kinase|calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase|hCASK|peripheral plasma membrane protein CASK|protein lin-2 homolog|trinucleotide repeat containing 8
Swissprots Q9BYH6 Q9NYB3 Q66T42 Q5VT18 B7ZKY0 Q9NYB2 Q5VT16 Q59HA0 O43215 Q5VT19 A6NES1 Q5VT17 O14936 Q17RI4
Accessions EAW59390 EAW59391 EAW59392 EAW59393 O14936 AB039327 BAB12252 AB208859 BAD92096 AF032119 AAB88125 AF035582 AAB88198 AF262404 AAF72666 AF262405 AAF72667 AK025872 AK056476 AK313399 AY705392 AAU10527 BC029936 BC035990 BC117311 AAI17312 BC143454 AAI43455 BC143456 AAI43457 DN993605 HQ258518 ADR83272 LN607837 CEF49524 XM_005272686 XP_005272743 XM_006724566 XP_006724629 XM_011543993 XP_011542295 XM_011543994 XP_011542296 XM_011543995 XP_011542297 XM_011543996 XP_011542298 XM_011543997 XP_011542299 NM_001126054 NP_001119526 NM_001126055 NP_001119527 NM_003688 NP_003679
Function Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver. {ECO:0000269|PubMed:11003712}.
Top Pathways Tight junction

CASK (D38F6) Rabbit mAb - 9497 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D38F6
Western blot analysis of extracts from rat and mouse brain using CASK (D38F6) Rabbit mAb.

CASK Antibody - 2878 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from mouse and rat brain, using CASK Antibody.

CASK (D24B12) Rabbit mAb - 8968 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D24B12
Western blot analysis of extracts from various tissues using CASK (D24B12) Rabbit mAb.

CASK (D14E3) Rabbit mAb - 8096 from Cell Signaling Technology

Host Rabbit
Clonality Monoclonal
Clone D14E3

CASK (H-107) - sc-10777 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CASK (H-107): sc-10777. Western blot analysis of CASK expression in c4 whole cell lysate.

CASK (C-6) - sc-13158 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CASK siRNA (h): sc-29920. Western blot analysis of CASK expression in non-transfected control (A) and CASK siRNA transfected (B) HeLa cells. Blot probed with CASK (C-6): sc-13158. α-actinin (H-2): sc-17829 used as specificity and loading control.

CASK (N-17) - sc-11202 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CASK (N-17): sc-11202. Western blot analysis of CASK expression in c4 whole cell lysate.

CASK (7) - sc-135857 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
CASK (7): sc-135857. Western blot analysis of CASK expression in rat cerebrum tissue extract.

Anti-CASK antibody - ab185932 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat lung tissue labelling CASK with ab185932 at 1/100. Magnification: 400x.

Anti-CASK antibody - ab3383 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CASK antibody - ab101815 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-CASK antibody [EPR6514(2)] - ab137032 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6514(2)
All lanes : Anti-CASK antibody [EPR6514(2)] (ab137032) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : Fetal kidney lysateLane 3 : HACAT cell lysateLane 4 : BxPC3 cell lysateLane 5 : SH-SY5Y cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP conjugated Goat anti Rabbit IgG at 1/2000 dilution

Anti-CASK antibody [EPR6515] - ab126609 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6515
Overlay histogram showing SHSY-5Y cells stained with ab126609 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab126609, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in SHSY-5Y cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-CASK antibody [S56A-50] - ab99039 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S56A-50
ab99039 staining CASK in Mouse brain tissue sections by Immunohistochemistry (IHC-Fr - frozen sections).

Anti-CASK antibody [S56A-50] (Biotin) - ab183425 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S56A-50

Anti-CASK antibody [S56A-50] (FITC) - ab183423 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S56A-50

Anti-CASK antibody [S56A-50] (HRP) - ab183424 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S56A-50

Anti-CASK antibody - N-terminal - ab189938 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CASK antibody - N-terminal (ab189938) at 1 µg/mlLane 1 : Mouse brain tissue lysateLane 2 : Mouse brain tissue lysate with immunizing peptide

Anti-CASK Antibody (C-Terminus) - LS-C4301 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CASK Antibody (aa578-592) - LS-C77570 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CASK Antibody (clone S56A-50) - LS-C153142 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S56A-50

Anti-CASK Antibody (aa318-415, clone S56A-50, Atto 565) - LS-C228169 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone S56A-50

Anti-CASK Antibody (aa318-415, clone S56A-50, Atto 488) - LS-C228168 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone S56A-50

Anti-CASK Antibody (aa318-415, clone S56A-50, Atto 390) - LS-C228167 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone S56A-50

Anti-CASK Antibody (aa318-415, clone S56A-50, Atto 594) - LS-C228170 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone S56A-50
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