NKX2-5
| Gene Symbol | NKX2-5 |
|---|---|
| Entrez Gene | 1482 |
| Alt Symbol | CHNG5, CSX, CSX1, HLHS2, NKX2.5, NKX2E, NKX4-1, VSD3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | NK2 homeobox 5 |
| Other Description | NK2 transcription factor related, locus 5|cardiac-specific homeobox 1|homeobox protein CSX|homeobox protein NK-2 homolog E|homeobox protein Nkx-2.5|tinman paralog |
| Swissprots | P52952 E9PBU6 B4DNB6 A8K3K0 |
| Accessions | ABL63553 ABL63554 ABL63555 ABL63556 ABL63557 ABL63558 ABL63559 ABL63560 ABL63561 ABL63562 ABL63563 ABL63564 ABL63565 ABL63566 ABL63567 ABL63568 ABL63569 ABL63570 ABL63571 ABL63572 ABL63573 ABL63574 ABL63575 ABL63576 ABL63577 ABL63578 ABL63579 ABL63580 ABL63581 ABL63582 ABL63583 ABL63584 ABL63585 ABL63586 ABL63587 ABL63588 ABL63589 ABL63590 ABL63591 ABL63592 ABL63593 ABL63594 ABL63595 ABL63596 ABL63597 ABL63598 ABL63599 ABL63600 ABL63601 ABL63602 ABL63603 ABL63604 ABL63605 ABL63606 ABL63607 ABL63608 ABL63609 ABL63610 ABL63611 ABL63612 ABL63613 ABL63614 ABL63615 ABL63616 ABL63617 ABL63618 ABL63619 ABL63620 ABL63621 ABL63622 ABL63623 ABL63624 ABL63625 ABL63626 ABL63627 ABL63628 ABL63629 ABL63630 ABL63631 ABL63632 ABL63633 ABL63634 ABL63635 ABL63636 EAW61404 P52952 AB021133 BAA35181 AI609745 AK290615 BAF83304 AK297844 BAG60178 AK307218 AK307247 AK307249 AK309495 BC025711 AAH25711 DA559427 DQ893313 ABM84239 DQ894104 ABM85030 DQ896627 ABM87626 U34962 AAC50470 NM_001166175 NP_001159647 NM_001166176 NP_001159648 NM_004387 NP_004378 |
| Function | Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development. {ECO:0000250, ECO:0000269|PubMed:22560297}. |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Tissue Specificity | Expressed only in the heart. |
Nkx-2.5 CRISPR/Cas9 KO Plasmid (h) - sc-400276 from Santa Cruz Biotechnology
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Nkx-2.5 HDR Plasmid (h) - sc-400276-HDR from Santa Cruz Biotechnology
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Nkx-2.5 Double Nickase Plasmid (h) - sc-400276-NIC from Santa Cruz Biotechnology
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Nkx-2.5 Double Nickase Plasmid (h2) - sc-400276-NIC-2 from Santa Cruz Biotechnology
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Nkx-2.5 CRISPR Activation Plasmid (h) - sc-400276-ACT from Santa Cruz Biotechnology
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Nkx-2.5 CRISPR Activation Plasmid (h2) - sc-400276-ACT-2 from Santa Cruz Biotechnology
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Nkx-2.5 Lentiviral Activation Particles (h) - sc-400276-LAC from Santa Cruz Biotechnology
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Nkx-2.5 Lentiviral Activation Particles (h2) - sc-400276-LAC-2 from Santa Cruz Biotechnology
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Nkx-2.5 siRNA (h) - sc-36075 from Santa Cruz Biotechnology
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Nkx-2.5 shRNA Plasmid (h) - sc-36075-SH from Santa Cruz Biotechnology
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Nkx-2.5 shRNA (h) Lentiviral Particles - sc-36075-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN15333 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15333 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03265 from Sigma-Aldrich
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NKX2-5 siRNA (Human) - CRH1048 from Cohesion Biosciences
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NKX2.5 RNAi - H00001482-R01 from Novus Biologicals
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Nkx-2.5 CRISPR/Cas9 KO Plasmid (h2) - sc-400276-KO-2 from Santa Cruz Biotechnology
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Nkx-2.5 HDR Plasmid (h2) - sc-400276-HDR-2 from Santa Cruz Biotechnology
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Human NKX2-5 siRNA - orb261550 from Biorbyt
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NKX2-5 shRNA Plasmid (Human) - CHH1048 from Cohesion Biosciences
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NKX2-5 miRNA 3'UTR clone - MiUTR3H-03496 from Creative biogene
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NKX2-5 miRNA 3'UTR clone - MiUTR3H-03497 from Creative biogene
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NKX2-5 miRNA 3'UTR clone - MiUTR3H-03498 from Creative biogene
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