| Gene Symbol | PLAUR |
|---|---|
| Entrez Gene | 5329 |
| Alt Symbol | CD87, U-PAR, UPAR, URKR |
| Species | Human |
| Gene Type | protein-coding |
| Description | plasminogen activator, urokinase receptor |
| Other Description | monocyte activation antigen Mo3|u-plasminogen activator receptor form 2|urokinase plasminogen activator surface receptor|urokinase-type plasminogen activator (uPA) receptor |
| Swissprots | Q9UMV0 Q6IB52 Q12876 A8K409 Q9UM92 Q16887 Q9UEA6 Q03405 Q9UD69 Q15845 Q9BWT0 Q9NYC8 |
| Accessions | AAA17979 AAB60690 AAC32739 AAD14289 AAD17387 AAD17388 AAD17389 AAN86351 AAT52166 AAT52167 AAT52168 CAO02271 EAW57215 EAW57216 EAW57217 EAW57218 EAW57219 EAW57220 Q03405 A18757 CAA01421 AA337688 AA643630 AF257789 AAF71751 AI801128 AI912302 AK290774 BAF83463 AY029180 AAK31795 BC002788 AAH02788 BY996586 CA495321 CD370232 CF126152 CR456952 CAG33233 DQ893017 ABM83943 DQ896262 ABM87261 M83246 AAA59862 U08839 AAB60333 U09347 AAA17978 X51675 CAA35981 X74039 CAA52191 XM_005258990 XP_005259047 XM_011527027 XP_011525329 XM_011527028 XP_011525330 XM_011527029 XP_011525331 XM_011527030 XP_011525332 XM_011527031 XP_011525333 NM_001005376 NP_001005376 NM_001005377 NP_001005377 NM_001301037 NP_001287966 NM_002659 NP_002650 |
| Function | Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. |
| Subcellular Location | Isoform 2: Secreted {ECO:0000305}. |
| Tissue Specificity | Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. |
| Top Pathways | Complement and coagulation cascades, Proteoglycans in cancer |
uPAR CRISPR/Cas9 KO Plasmid (h) - sc-400666 from Santa Cruz Biotechnology
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uPAR HDR Plasmid (h) - sc-400666-HDR from Santa Cruz Biotechnology
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uPAR Double Nickase Plasmid (h) - sc-400666-NIC from Santa Cruz Biotechnology
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uPAR Double Nickase Plasmid (h2) - sc-400666-NIC-2 from Santa Cruz Biotechnology
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uPAR CRISPR Activation Plasmid (h) - sc-400666-ACT from Santa Cruz Biotechnology
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uPAR CRISPR Activation Plasmid (h2) - sc-400666-ACT-2 from Santa Cruz Biotechnology
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uPAR Lentiviral Activation Particles (h) - sc-400666-LAC from Santa Cruz Biotechnology
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uPAR Lentiviral Activation Particles (h2) - sc-400666-LAC-2 from Santa Cruz Biotechnology
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uPAR siRNA (h) - sc-36781 from Santa Cruz Biotechnology
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uPAR shRNA Plasmid (h) - sc-36781-SH from Santa Cruz Biotechnology
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uPAR shRNA (h) Lentiviral Particles - sc-36781-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU125271 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16916 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16916 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02988 from Sigma-Aldrich
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PLAUR siRNA (Human) - CRH3569 from Cohesion Biosciences
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shRNA set against Human PLAUR (NM_002659.3) - SHH377060 from Creative biogene
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Human PLAUR siRNA - orb264071 from Biorbyt
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PLAUR shRNA Plasmid (Human) - CHH3569 from Cohesion Biosciences
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PLAUR miRNA 3'UTR clone - MiUTR3H-01774 from Creative biogene
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PLAUR miRNA 3'UTR clone - MiUTR3H-01775 from Creative biogene
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PLAUR miRNA 3'UTR clone - MiUTR3H-01776 from Creative biogene
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