| Gene Symbol |
BAZ2A
|
| Entrez Gene |
11176
|
| Alt Symbol |
TIP5, WALp3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
bromodomain adjacent to zinc finger domain, 2A
|
| Other Description |
TTF-I interacting peptide 5|TTF-I-interacting protein 5|bromodomain adjacent to zinc finger domain protein 2A|transcription termination factor I-interacting protein 5
|
| Swissprots |
Q68DI8 B3KN66 O00536 Q96H26 O15030 Q9UIF9
|
| Accessions |
EAW96949 EAW96950 EAW96951 Q9UIF9 AB002312 BAA20773 AF000422 AAB60864 AK023830 BAG51228 AK023842 AK127775 AK303327 BAH13943 BC008965 AAH08965 BC065914 BC152739 AAI52740 CD686304 CR749379 CAH18232 DB215236 XM_011537797 XP_011536099 XM_011537798 XP_011536100 XM_011537799 XP_011536101 XM_011537800 XP_011536102 XM_011537801 XP_011536103 XM_011537802 XP_011536104 XM_011537803 XP_011536105 XM_011537804 XP_011536106 XM_011537805 XP_011536107 XM_011537806 XP_011536108 XM_011537807 XP_011536109 XM_011537808 XP_011536110 XM_011537809 XP_011536111 NM_001300905 NP_001287834 NM_013449 NP_038477
|
| Function |
Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys- 16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA- binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000250}. Note=Colocalizes with the basal RNA polymerase I transcription factor UBF in the nucleolus. {ECO:0000250}.
|
| Tissue Specificity |
Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.
|