BAZ2A
| Gene Symbol | BAZ2A |
|---|---|
| Entrez Gene | 11176 |
| Alt Symbol | TIP5, WALp3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | bromodomain adjacent to zinc finger domain, 2A |
| Other Description | TTF-I interacting peptide 5|TTF-I-interacting protein 5|bromodomain adjacent to zinc finger domain protein 2A|transcription termination factor I-interacting protein 5 |
| Swissprots | Q68DI8 B3KN66 O00536 Q96H26 O15030 Q9UIF9 |
| Accessions | EAW96949 EAW96950 EAW96951 Q9UIF9 AB002312 BAA20773 AF000422 AAB60864 AK023830 BAG51228 AK023842 AK127775 AK303327 BAH13943 BC008965 AAH08965 BC065914 BC152739 AAI52740 CD686304 CR749379 CAH18232 DB215236 XM_011537797 XP_011536099 XM_011537798 XP_011536100 XM_011537799 XP_011536101 XM_011537800 XP_011536102 XM_011537801 XP_011536103 XM_011537802 XP_011536104 XM_011537803 XP_011536105 XM_011537804 XP_011536106 XM_011537805 XP_011536107 XM_011537806 XP_011536108 XM_011537807 XP_011536109 XM_011537808 XP_011536110 XM_011537809 XP_011536111 NM_001300905 NP_001287834 NM_013449 NP_038477 |
| Function | Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys- 16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA- binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus, nucleolus {ECO:0000250}. Note=Colocalizes with the basal RNA polymerase I transcription factor UBF in the nucleolus. {ECO:0000250}. |
| Tissue Specificity | Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. |
BAZ2A CRISPR/Cas9 KO Plasmid (h) - sc-411582 from Santa Cruz Biotechnology
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BAZ2A HDR Plasmid (h) - sc-411582-HDR from Santa Cruz Biotechnology
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BAZ2A Double Nickase Plasmid (h) - sc-411582-NIC from Santa Cruz Biotechnology
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BAZ2A Double Nickase Plasmid (h2) - sc-411582-NIC-2 from Santa Cruz Biotechnology
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BAZ2A CRISPR Activation Plasmid (h) - sc-411582-ACT from Santa Cruz Biotechnology
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BAZ2A CRISPR Activation Plasmid (h2) - sc-411582-ACT-2 from Santa Cruz Biotechnology
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BAZ2A Lentiviral Activation Particles (h) - sc-411582-LAC from Santa Cruz Biotechnology
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BAZ2A Lentiviral Activation Particles (h2) - sc-411582-LAC-2 from Santa Cruz Biotechnology
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BAZ2A siRNA (h) - sc-96182 from Santa Cruz Biotechnology
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BAZ2A shRNA Plasmid (h) - sc-96182-SH from Santa Cruz Biotechnology
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BAZ2A shRNA (h) Lentiviral Particles - sc-96182-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU014601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3874 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3874 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR13841 from Sigma-Aldrich
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BAZ2A siRNA (Human) - CRH7656 from Cohesion Biosciences
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BAZ2A RNAi - H00011176-R01 from Novus Biologicals
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BAZ2A - MBS8227612 from MyBioSource
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shRNA set against Human BAZ2A (NM_013449.3) - SHH245046 from Creative biogene
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shRNA set against Human BAZ2A(NM_013449.3) - SHG091907 from Creative biogene
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Human BAZ2A siRNA - orb268158 from Biorbyt
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BAZ2A shRNA Plasmid (Human) - CHH7656 from Cohesion Biosciences
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BAZ2A miRNA 3'UTR clone - MiUTR1H-00819 from Creative biogene
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