SCIMP
| Gene Symbol | SCIMP |
|---|---|
| Entrez Gene | 388325 |
| Alt Symbol | C17orf87, UNQ5783 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SLP adaptor and CSK interacting membrane protein |
| Other Description | DTFT5783|SLP adapter and CSK-interacting membrane protein|SLP65/SLP76, Csk-interacting membrane protein|transmembrane protein C17orf87 |
| Swissprots | B4DLK1 A6XGL4 Q6UWF3 Q96MD0 |
| Accessions | EAW90348 EAW90349 EAW90350 Q6UWF3 AK057142 AK297035 BAG59563 AK310145 AY358809 AAQ89169 BC127925 AAI27926 BC130554 AAI30555 BC130556 AAI30557 BC144395 AAI44396 DQ778084 ABI63348 HQ258063 ADR82817 HQ258597 ADR83350 XM_005256631 XP_005256688 NM_001271842 NP_001258771 NM_207103 NP_996986 |
| Function | Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation. {ECO:0000269|PubMed:21930792}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:21930792}; Lipid-anchor {ECO:0000269|PubMed:21930792}. Note=Together with MHC-II, associates with lipid-enriched microdomains called tetraspanin-enriched microdomains (TEMs). Rapidly translocates into immunological synapse (IS) at cell-cell contacts between antigen-presenting cells (APCs) and T-cells. Colocalized with tetraspanins CD37, CD53, and CD81 at the uropod. Present at regions of cell-cell contacts but also at the leading edge of migrating cells. |
| Tissue Specificity | Expressed in antigen-presenting cells, like peripheral blood leukocytes and monocyte-derived dendritic cells (MDDC) (at protein level). Highly expressed in lymph nodes and spleen. Expressed in antigen-presenting cells. Faintly expressed in the majority of nonimmune system tissues. {ECO:0000269|PubMed:21930792}. |
Anti-C17orf87 antibody - ab121246 from Abcam
|
||||||||||
Anti-C17orf87 antibody [NVL-07] - ab166984 from Abcam
|
||||||||||
Anti-SCIMP Antibody (clone NVL-07) - LS-C204341 from LifeSpan Bioscience
|
||||||||||
SCIMP Antibody (NVL-07) - NBP2-22349 from Novus Biologicals
|
||||||||||
SCIMP Antibody (NVL-07) [7C] - NBP2-22349V2 from Novus Biologicals
|
||||||||||
SCIMP Antibody (NVL-07) [DyLight 680] - NBP2-22349FR from Novus Biologicals
|
||||||||||
SCIMP Antibody (NVL-07) [DyLight 405] - NBP2-22349V from Novus Biologicals
|
||||||||||
SCIMP Antibody (NVL-07) [DyLight 350] - NBP2-22349UV from Novus Biologicals
|
||||||||||
SCIMP Antibody (NVL-07) [PE] - NBP2-22349PE from Novus Biologicals
|
||||||||||
SCIMP Antibody (NVL-07) [PerCP] - NBP2-22349PCP from Novus Biologicals
|
||||||||||
SCIMP Antibody (NVL-07) [DyLight 405LS] - NBP2-22349V3 from Novus Biologicals
|
||||||||||
SCIMP Antibody (NVL-07) [DyLight 755] - NBP2-22349IR from Novus Biologicals
|
||||||||||
SCIMP Antibody (NVL-07) [Allophycocyanin] - NBP2-22349APC from Novus Biologicals
|
||||||||||
SCIMP Antibody (NVL-07) [DyLight 488] - NBP2-22349G from Novus Biologicals
|
||||||||||
SCIMP Antibody (NVL-07) [Alexa Fluor (R) 647] - NBP2-22349AF647 from Novus Biologicals
|
||||||||||
SCIMP Antibody (NVL-07) [Alexa Fluor (R) 488] - NBP2-22349AF488 from Novus Biologicals
|
||||||||||
SCIMP Antibody (NVL-07) [Alexa Fluor (R) 405] - NBP2-22349AF405 from Novus Biologicals
|
||||||||||
SCIMP Antibody (NVL-07) [Alexa Fluor (R) 700] - NBP2-22349AF700 from Novus Biologicals
|
||||||||||
C17orf87 Polyclonal Antibody - bs-13685R from Bioss
|
||||||||||
C17orf87 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13685R-A350 from Bioss
|
||||||||||
C17orf87 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13685R-A488 from Bioss
|
||||||||||
C17orf87 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13685R-A555 from Bioss
|
||||||||||
C17orf87 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-13685R-A647 from Bioss
|
||||||||||
C17orf87 Polyclonal Antibody, Cy3 Conjugated - bs-13685R-Cy3 from Bioss
|
||||||||||
C17orf87 Polyclonal Antibody, Cy5 Conjugated - bs-13685R-Cy5 from Bioss
|