| Gene Symbol |
SCIMP
|
| Entrez Gene |
388325
|
| Alt Symbol |
C17orf87, UNQ5783
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SLP adaptor and CSK interacting membrane protein
|
| Other Description |
DTFT5783|SLP adapter and CSK-interacting membrane protein|SLP65/SLP76, Csk-interacting membrane protein|transmembrane protein C17orf87
|
| Swissprots |
B4DLK1 A6XGL4 Q6UWF3 Q96MD0
|
| Accessions |
EAW90348 EAW90349 EAW90350 Q6UWF3 AK057142 AK297035 BAG59563 AK310145 AY358809 AAQ89169 BC127925 AAI27926 BC130554 AAI30555 BC130556 AAI30557 BC144395 AAI44396 DQ778084 ABI63348 HQ258063 ADR82817 HQ258597 ADR83350 XM_005256631 XP_005256688 NM_001271842 NP_001258771 NM_207103 NP_996986
|
| Function |
Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation. {ECO:0000269|PubMed:21930792}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:21930792}; Lipid-anchor {ECO:0000269|PubMed:21930792}. Note=Together with MHC-II, associates with lipid-enriched microdomains called tetraspanin-enriched microdomains (TEMs). Rapidly translocates into immunological synapse (IS) at cell-cell contacts between antigen-presenting cells (APCs) and T-cells. Colocalized with tetraspanins CD37, CD53, and CD81 at the uropod. Present at regions of cell-cell contacts but also at the leading edge of migrating cells.
|
| Tissue Specificity |
Expressed in antigen-presenting cells, like peripheral blood leukocytes and monocyte-derived dendritic cells (MDDC) (at protein level). Highly expressed in lymph nodes and spleen. Expressed in antigen-presenting cells. Faintly expressed in the majority of nonimmune system tissues. {ECO:0000269|PubMed:21930792}.
|