SCIMP

Gene Symbol SCIMP
Entrez Gene 388325
Alt Symbol C17orf87, UNQ5783
Species Human
Gene Type protein-coding
Description SLP adaptor and CSK interacting membrane protein
Other Description DTFT5783|SLP adapter and CSK-interacting membrane protein|SLP65/SLP76, Csk-interacting membrane protein|transmembrane protein C17orf87
Swissprots B4DLK1 A6XGL4 Q6UWF3 Q96MD0
Accessions EAW90348 EAW90349 EAW90350 Q6UWF3 AK057142 AK297035 BAG59563 AK310145 AY358809 AAQ89169 BC127925 AAI27926 BC130554 AAI30555 BC130556 AAI30557 BC144395 AAI44396 DQ778084 ABI63348 HQ258063 ADR82817 HQ258597 ADR83350 XM_005256631 XP_005256688 NM_001271842 NP_001258771 NM_207103 NP_996986
Function Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation. {ECO:0000269|PubMed:21930792}.
Subcellular Location Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:21930792}; Lipid-anchor {ECO:0000269|PubMed:21930792}. Note=Together with MHC-II, associates with lipid-enriched microdomains called tetraspanin-enriched microdomains (TEMs). Rapidly translocates into immunological synapse (IS) at cell-cell contacts between antigen-presenting cells (APCs) and T-cells. Colocalized with tetraspanins CD37, CD53, and CD81 at the uropod. Present at regions of cell-cell contacts but also at the leading edge of migrating cells.
Tissue Specificity Expressed in antigen-presenting cells, like peripheral blood leukocytes and monocyte-derived dendritic cells (MDDC) (at protein level). Highly expressed in lymph nodes and spleen. Expressed in antigen-presenting cells. Faintly expressed in the majority of nonimmune system tissues. {ECO:0000269|PubMed:21930792}.

C17orf87 CRISPR/Cas9 KO Plasmid (h) - sc-415771 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C17orf87 HDR Plasmid (h) - sc-415771-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C17orf87 Double Nickase Plasmid (h) - sc-415771-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C17orf87 Double Nickase Plasmid (h2) - sc-415771-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C17orf87 CRISPR Activation Plasmid (h) - sc-415771-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C17orf87 CRISPR Activation Plasmid (h2) - sc-415771-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C17orf87 Lentiviral Activation Particles (h) - sc-415771-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C17orf87 Lentiviral Activation Particles (h2) - sc-415771-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C17orf87 siRNA (h) - sc-94149 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

C17orf87 shRNA Plasmid (h) - sc-94149-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

C17orf87 shRNA (h) Lentiviral Particles - sc-94149-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU138221 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN4491 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4491 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03331 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03331

SCIMP siRNA (Human) - CRJ7787 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SCIMP - MBS827250 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human C17orf87 (NM_207103.2) - SHH249970 from Creative biogene

Category siRNA
Species Reactivities Human

SCIMP shRNA Plasmid (Human) - CHJ7787 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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