| Gene Symbol |
NPW
|
| Entrez Gene |
283869
|
| Alt Symbol |
L8, L8C, PPL8, PPNPW
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neuropeptide W
|
| Other Description |
hPPL8|prepro-neuropeptide W|preproprotein L8
|
| Swissprots |
Q8N729
|
| Accessions |
Q8N729 AB084276 BAC07172 AL365519 AL365521 BC150534 AAI50535 BC160149 AAI60149 BC171886 BM985063 CK817957 NM_001099456 NP_001092926
|
| Function |
Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. {ECO:0000250}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma.
|