Gene Symbol | NPW |
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Entrez Gene | 283869 |
Alt Symbol | L8, L8C, PPL8, PPNPW |
Species | Human |
Gene Type | protein-coding |
Description | neuropeptide W |
Other Description | hPPL8|prepro-neuropeptide W|preproprotein L8 |
Swissprots | Q8N729 |
Accessions | Q8N729 AB084276 BAC07172 AL365519 AL365521 BC150534 AAI50535 BC160149 AAI60149 BC171886 BM985063 CK817957 NM_001099456 NP_001092926 |
Function | Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. {ECO:0000250}. |
Subcellular Location | Secreted. |
Tissue Specificity | Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma. |
NPW CRISPR/Cas9 KO Plasmid (h) - sc-415337 from Santa Cruz Biotechnology
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NPW HDR Plasmid (h) - sc-415337-HDR from Santa Cruz Biotechnology
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NPW Double Nickase Plasmid (h) - sc-415337-NIC from Santa Cruz Biotechnology
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NPW Double Nickase Plasmid (h2) - sc-415337-NIC-2 from Santa Cruz Biotechnology
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NPW CRISPR Activation Plasmid (h) - sc-415337-ACT from Santa Cruz Biotechnology
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NPW CRISPR Activation Plasmid (h2) - sc-415337-ACT-2 from Santa Cruz Biotechnology
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NPW Lentiviral Activation Particles (h) - sc-415337-LAC from Santa Cruz Biotechnology
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NPW Lentiviral Activation Particles (h2) - sc-415337-LAC-2 from Santa Cruz Biotechnology
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NPW siRNA (h) - sc-93473 from Santa Cruz Biotechnology
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NPW shRNA Plasmid (h) - sc-93473-SH from Santa Cruz Biotechnology
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NPW shRNA (h) Lentiviral Particles - sc-93473-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN15477 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15477 from Sigma-Aldrich
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NPW siRNA (Human) - CRJ6940 from Cohesion Biosciences
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shRNA set against Human NPW (NM_001099456.2) - SHH354524 from Creative biogene
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Human NPW siRNA - orb277441 from Biorbyt
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NPW shRNA Plasmid (Human) - CHJ6940 from Cohesion Biosciences
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