Gene Symbol | ABCA1 |
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Entrez Gene | 19 |
Alt Symbol | ABC-1, ABC1, CERP, HDLDT1, TGD |
Species | Human |
Gene Type | protein-coding |
Description | ATP-binding cassette, sub-family A (ABC1), member 1 |
Other Description | ATP-binding cassette sub-family A member 1|ATP-binding cassette transporter A1|cholesterol efflux regulatory protein|membrane-bound |
Swissprots | Q96S56 O95477 Q9NQV4 Q9UN06 Q9UN08 Q9UN07 Q5VX33 Q96T85 Q9UN09 |
Accessions | AAD49851 AAD49852 AAD49853 AAD49854 AAF86276 AAK43526 CAC21428 CCQ43324 EAW58992 EAW58993 EAW58994 O95477 AB037924 BAB07875 AB055982 BAB63210 AB208839 BAD92076 AB445477 BAH10664 AF165281 AAD49849 AF258627 AAF69513 AF285167 AAF98175 AJ012376 CAA10005 AK024328 AK027864 BC034824 BC146856 AAI46857 BU753834 BX955241 XM_005251773 XP_005251830 XM_005251776 XP_005251833 XM_011518339 XP_011516641 XM_011518340 XP_011516642 XM_011518341 XP_011516643 XM_011518342 XP_011516644 XM_011518343 XP_011516645 XM_011518344 XP_011516646 NM_005502 NP_005493 |
Function | cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport. |
Subcellular Location | Membrane {ECO:0000269|PubMed:19258317, ECO:0000269|PubMed:19556522}; Multi-pass membrane protein {ECO:0000269|PubMed:19258317, ECO:0000269|PubMed:19556522}. |
Tissue Specificity | Widely expressed, but most abundant in macrophages. |
Top Pathways | ABC transporters, Fat digestion and absorption |
ABC1 CRISPR/Cas9 KO Plasmid (h) - sc-401086 from Santa Cruz Biotechnology
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ABC1 HDR Plasmid (h) - sc-401086-HDR from Santa Cruz Biotechnology
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ABC1 Double Nickase Plasmid (h) - sc-401086-NIC from Santa Cruz Biotechnology
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ABC1 Double Nickase Plasmid (h2) - sc-401086-NIC-2 from Santa Cruz Biotechnology
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ABC1 CRISPR Activation Plasmid (h) - sc-401086-ACT from Santa Cruz Biotechnology
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ABC1 CRISPR Activation Plasmid (h2) - sc-401086-ACT-2 from Santa Cruz Biotechnology
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ABC1 Lentiviral Activation Particles (h) - sc-401086-LAC from Santa Cruz Biotechnology
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ABC1 Lentiviral Activation Particles (h2) - sc-401086-LAC-2 from Santa Cruz Biotechnology
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ABC1 siRNA (h) - sc-41136 from Santa Cruz Biotechnology
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ABC1 shRNA Plasmid (h) - sc-41136-SH from Santa Cruz Biotechnology
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ABC1 shRNA (h) Lentiviral Particles - sc-41136-V from Santa Cruz Biotechnology
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ABCA1 RNAi - H00000019-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN1200 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1105 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1200 from Sigma-Aldrich
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ABCA1 siRNA (Human) - CRH0011 from Cohesion Biosciences
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ABCA1 - MBS8212552 from MyBioSource
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shRNA set against Human ABCA1 (NM_005502.3) - SHH228758 from Creative biogene
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Human ABCA1 siRNA - orb260513 from Biorbyt
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ABCA1 shRNA Plasmid (Human) - CHH0011 from Cohesion Biosciences
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ABCA1 miRNA 3'UTR clone - MiUTR3H-03106 from Creative biogene
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