| Gene Symbol | NONO |
|---|---|
| Entrez Gene | 4841 |
| Alt Symbol | NMT55, NRB54, P54, P54NRB, PPP1R114 |
| Species | Human |
| Gene Type | protein-coding |
| Description | non-POU domain containing, octamer-binding |
| Other Description | 54 kDa nuclear RNA- and DNA-binding protein|55 kDa nuclear protein|DNA-binding p52/p100 complex, 52 kDa subunit|non-POU domain-containing octamer (ATGCAAAT) binding protein|non-POU domain-containing octamer-binding protein|p54(nrb)|protein phosphatase 1, regulatory subunit 114 |
| Swissprots | O00201 B7Z4C2 Q15233 Q12786 P30807 Q9BQC5 F5GYZ3 D3DVV4 |
| Accessions | CAA72157 EAX05298 EAX05299 EAX05300 Q15233 AK055406 AK291140 BAF83829 AK297144 BAH12508 AU119361 BC002364 AAH02364 BC003129 AAH03129 BC004113 BC010049 BC012141 AAH12141 BC025280 BC025352 BC028299 AAH28299 BC069616 AAH69616 BC069639 AAH69639 CR456761 CAG33042 DA116840 DA779425 L14599 AAC37578 L32558 AAA36727 U02493 AAA03427 U89867 AAC51852 NM_001145408 NP_001138880 NM_001145409 NP_001138881 NM_001145410 NP_001138882 NM_007363 NP_031389 |
| Function | DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRC |
| Subcellular Location | Nucleus. Nucleus, nucleolus. Nucleus speckle. Note=Detected in punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. |
| Tissue Specificity | Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Also found in a number of breast tumor cell lines. {ECO:0000269|PubMed:9341872}. |