NONO

Gene Symbol	NONO
Entrez Gene	4841
Alt Symbol	NMT55, NRB54, P54, P54NRB, PPP1R114
Species	Human
Gene Type	protein-coding
Description	non-POU domain containing, octamer-binding
Other Description	54 kDa nuclear RNA- and DNA-binding protein|55 kDa nuclear protein|DNA-binding p52/p100 complex, 52 kDa subunit|non-POU domain-containing octamer (ATGCAAAT) binding protein|non-POU domain-containing octamer-binding protein|p54(nrb)|protein phosphatase 1, regulatory subunit 114
Swissprots	O00201 B7Z4C2 Q15233 Q12786 P30807 Q9BQC5 F5GYZ3 D3DVV4
Accessions	CAA72157 EAX05298 EAX05299 EAX05300 Q15233 AK055406 AK291140 BAF83829 AK297144 BAH12508 AU119361 BC002364 AAH02364 BC003129 AAH03129 BC004113 BC010049 BC012141 AAH12141 BC025280 BC025352 BC028299 AAH28299 BC069616 AAH69616 BC069639 AAH69639 CR456761 CAG33042 DA116840 DA779425 L14599 AAC37578 L32558 AAA36727 U02493 AAA03427 U89867 AAC51852 NM_001145408 NP_001138880 NM_001145409 NP_001138881 NM_001145410 NP_001138882 NM_007363 NP_031389
Function	DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRC
Subcellular Location	Nucleus. Nucleus, nucleolus. Nucleus speckle. Note=Detected in punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles.
Tissue Specificity	Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Also found in a number of breast tumor cell lines. {ECO:0000269|PubMed:9341872}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human nmt55 / p54nrb peptide - ab45358 from Abcam Category Peptide

Human nmt55 / p54nrb peptide - ab50439 from Abcam Category Peptide Species Human

NONO / P54NRB Antibody Blocking Peptide - LS-E2702 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NONO / P54NRB Antibody Blocking Peptide - LS-E14915 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NONO / P54NRB Antibody Blocking Peptide - LS-E26094 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human NONO Protein - H00004841-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NONO-Antibody-N-term-Blocking-peptide - BP13781a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

p54nrb blocking peptide - GTX89315-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

NONO Immunizing peptide - orb15160 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

NONO Blocking Peptide - 33R-1969 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NONO Blocking Peptide - 33R-4610 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

nmt55 / p54nrb Peptide - AC21-0922-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NONO / NMT55 - H00004841-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NONO / NMT55 - H00004841-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NONO Peptide - 45-976P from ProSci Category Peptide Species Human, Mouse

NONO fusion protein - ag17609 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

NONO fusion protein - ag1512 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

NonO Peptide - 350545 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

Recombinant Human NONO, His-tagged - NONO-28748TH from Creative Biomart Category Protein Source E. coli

Recombinant Human NONO, His-tagged - NONO-1332H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Non POU Domain Containing Octamer Binding Protein (NONO) - RPJ818Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Human Non-POU domain-containing octamer-binding protein(NONO) - CSB-YP624018HU CSB-EP624018HU CSB-BP624018HU CSB-MP624018HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MonoMethyl-NONO-R357/R365 Peptide - abx165208 from Abbexa Category Peptide Species Human

NONO / NMT55 (transcript variant 2) - TP306688 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

NONO / NMT55 (transcript variant 1) - TP326567 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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