| Gene Symbol |
MBOAT2
|
| Entrez Gene |
129642
|
| Alt Symbol |
LPCAT4, OACT2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
membrane bound O-acyltransferase domain containing 2
|
| Other Description |
1-acylglycerophosphate O-acyltransferase|1-acylglycerophosphoethanolamine O-acyltransferase|LPAAT|LPEAT|LPLAT 2|O-acyltransferase (membrane bound) domain containing 2|O-acyltransferase domain-containing protein 2|lyso-PA acyltransferase|lyso-PE acyltransferase|lysophosphatidic acid acyltransferase|lysophosphatidylethanolamine acyltransferase|lysophospholipid acyltransferase 2|membrane-bound O-acyltransferase domain-containing protein 2
|
| Swissprots |
Q8NCE7 Q96KY4 Q6ZWT7 A9EDR2
|
| Accessions |
EAX01013 Q6ZWT7 AB305044 BAF93900 AF052107 AK027321 BAC85105 AK074779 BAC11204 AK295907 BAH12219 AK309818 AK315881 BAF98772 BC016005 AAH16005 BC146871 AAI46872 BC157827 AAI57828 XM_011510309 XP_011508611 XM_011510310 XP_011508612 XM_011510311 XP_011508613 XM_011510312 XP_011508614 XM_011510313 XP_011508615 XM_011510314 XP_011508616 XR_241248 NM_138799 NP_620154
|
| Function |
Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3- phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2- diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269|PubMed:18772128}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in neutrophils. {ECO:0000269|PubMed:18772128}.
|
| Top Pathways |
Glycerolipid metabolism, Glycerophospholipid metabolism
|
