| Gene Symbol | MBOAT2 |
|---|---|
| Entrez Gene | 129642 |
| Alt Symbol | LPCAT4, OACT2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | membrane bound O-acyltransferase domain containing 2 |
| Other Description | 1-acylglycerophosphate O-acyltransferase|1-acylglycerophosphoethanolamine O-acyltransferase|LPAAT|LPEAT|LPLAT 2|O-acyltransferase (membrane bound) domain containing 2|O-acyltransferase domain-containing protein 2|lyso-PA acyltransferase|lyso-PE acyltransferase|lysophosphatidic acid acyltransferase|lysophosphatidylethanolamine acyltransferase|lysophospholipid acyltransferase 2|membrane-bound O-acyltransferase domain-containing protein 2 |
| Swissprots | Q8NCE7 Q96KY4 Q6ZWT7 A9EDR2 |
| Accessions | EAX01013 Q6ZWT7 AB305044 BAF93900 AF052107 AK027321 BAC85105 AK074779 BAC11204 AK295907 BAH12219 AK309818 AK315881 BAF98772 BC016005 AAH16005 BC146871 AAI46872 BC157827 AAI57828 XM_011510309 XP_011508611 XM_011510310 XP_011508612 XM_011510311 XP_011508613 XM_011510312 XP_011508614 XM_011510313 XP_011508615 XM_011510314 XP_011508616 XR_241248 NM_138799 NP_620154 |
| Function | Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3- phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2- diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269|PubMed:18772128}. |
| Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed in neutrophils. {ECO:0000269|PubMed:18772128}. |
| Top Pathways | Glycerolipid metabolism, Glycerophospholipid metabolism |
MBOAT2 CRISPR/Cas9 KO Plasmid (h) - sc-414353 from Santa Cruz Biotechnology
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MBOAT2 HDR Plasmid (h) - sc-414353-HDR from Santa Cruz Biotechnology
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MBOAT2 Double Nickase Plasmid (h) - sc-414353-NIC from Santa Cruz Biotechnology
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MBOAT2 Double Nickase Plasmid (h2) - sc-414353-NIC-2 from Santa Cruz Biotechnology
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MBOAT2 CRISPR Activation Plasmid (h) - sc-414353-ACT from Santa Cruz Biotechnology
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MBOAT2 CRISPR Activation Plasmid (h2) - sc-414353-ACT-2 from Santa Cruz Biotechnology
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MBOAT2 Lentiviral Activation Particles (h) - sc-414353-LAC from Santa Cruz Biotechnology
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MBOAT2 Lentiviral Activation Particles (h2) - sc-414353-LAC-2 from Santa Cruz Biotechnology
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MBOAT2 siRNA (h) - sc-94980 from Santa Cruz Biotechnology
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MBOAT2 shRNA Plasmid (h) - sc-94980-SH from Santa Cruz Biotechnology
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MBOAT2 shRNA (h) Lentiviral Particles - sc-94980-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU095901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13090 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13090 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12850 from Sigma-Aldrich
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MBOAT2 siRNA (Human) - CRJ5006 from Cohesion Biosciences
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shRNA set against Human MBOAT2 (NM_138799.2) - SHH338947 from Creative biogene
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shRNA set against Human MBOAT2(NM_138799.2) - SHH179939 from Creative biogene
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Human MBOAT2 siRNA - orb275507 from Biorbyt
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MBOAT2 shRNA Plasmid (Human) - CHJ5006 from Cohesion Biosciences
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MBOAT2 miRNA 3'UTR clone - MiUTR1H-06140 from Creative biogene
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