| Gene Symbol | TNFRSF17 |
|---|---|
| Entrez Gene | 608 |
| Alt Symbol | BCM, BCMA, CD269, TNFRSF13A |
| Species | Human |
| Gene Type | protein-coding |
| Description | tumor necrosis factor receptor superfamily, member 17 |
| Other Description | B cell maturation antigen|B-cell maturation factor|B-cell maturation protein|tumor necrosis factor receptor superfamily member 17 |
| Swissprots | Q02223 Q2TQ40 |
| Accessions | AAB67251 AAR84240 BAB60895 CAA82690 CAJ90608 CAJ90610 EAW85129 Q02223 AY684975 AAV92616 BC058291 AAH58291 EF152353 ABN42508 EF152354 ABN42509 EF152355 ABN42510 EF152356 ABN42511 Z14954 CAA78679 Z29575 CAA82691 NM_001192 NP_001183 |
| Function | Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. {ECO:0000269|PubMed:10801128, ECO:0000269|PubMed:10903733, ECO:0000269|PubMed:10973284}. |
| Subcellular Location | Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures. |
| Tissue Specificity | Expressed in mature B-cells, but not in T- cells or monocytes. |
| Top Pathways | Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production |