Gene Symbol | TNFRSF17 |
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Entrez Gene | 608 |
Alt Symbol | BCM, BCMA, CD269, TNFRSF13A |
Species | Human |
Gene Type | protein-coding |
Description | tumor necrosis factor receptor superfamily, member 17 |
Other Description | B cell maturation antigen|B-cell maturation factor|B-cell maturation protein|tumor necrosis factor receptor superfamily member 17 |
Swissprots | Q02223 Q2TQ40 |
Accessions | AAB67251 AAR84240 BAB60895 CAA82690 CAJ90608 CAJ90610 EAW85129 Q02223 AY684975 AAV92616 BC058291 AAH58291 EF152353 ABN42508 EF152354 ABN42509 EF152355 ABN42510 EF152356 ABN42511 Z14954 CAA78679 Z29575 CAA82691 NM_001192 NP_001183 |
Function | Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. {ECO:0000269|PubMed:10801128, ECO:0000269|PubMed:10903733, ECO:0000269|PubMed:10973284}. |
Subcellular Location | Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures. |
Tissue Specificity | Expressed in mature B-cells, but not in T- cells or monocytes. |
Top Pathways | Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production |
BCMA CRISPR/Cas9 KO Plasmid (h) - sc-403058 from Santa Cruz Biotechnology
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BCMA HDR Plasmid (h) - sc-403058-HDR from Santa Cruz Biotechnology
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BCMA Double Nickase Plasmid (h) - sc-403058-NIC from Santa Cruz Biotechnology
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BCMA Double Nickase Plasmid (h2) - sc-403058-NIC-2 from Santa Cruz Biotechnology
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BCMA CRISPR Activation Plasmid (h) - sc-403058-ACT from Santa Cruz Biotechnology
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BCMA CRISPR Activation Plasmid (h2) - sc-403058-ACT-2 from Santa Cruz Biotechnology
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BCMA Lentiviral Activation Particles (h) - sc-403058-LAC from Santa Cruz Biotechnology
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BCMA Lentiviral Activation Particles (h2) - sc-403058-LAC-2 from Santa Cruz Biotechnology
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BCMA siRNA (h) - sc-40233 from Santa Cruz Biotechnology
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BCMA shRNA Plasmid (h) - sc-40233-SH from Santa Cruz Biotechnology
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BCMA shRNA (h) Lentiviral Particles - sc-40233-V from Santa Cruz Biotechnology
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BCMA/TNFRSF17 RNAi - H00000608-R02 from Novus Biologicals
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MISSION® esiRNA - EHU022961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21748 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21748 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12042 from Sigma-Aldrich
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TNFRSF17 siRNA (Human) - CRH0417 from Cohesion Biosciences
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TNFRSF17 - MBS8209581 from MyBioSource
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shRNA set against Human TNFRSF17 (NM_001192.2) - SHH431944 from Creative biogene
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shRNA set against Human TNFRSF17(NM_001192.2) - SHL084708 from Creative biogene
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TNFRSF17 shRNA Plasmid (Human) - CHH0417 from Cohesion Biosciences
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TNFRSF17 miRNA 3'UTR clone - MiUTR1H-10596 from Creative biogene
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