Gene Symbol | CHRNA9 |
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Entrez Gene | 55584 |
Alt Symbol | HSA243342, NACHRA9 |
Species | Human |
Gene Type | protein-coding |
Description | cholinergic receptor, nicotinic, alpha 9 (neuronal) |
Other Description | NACHR alpha 9|acetylcholine receptor, neuronal nicotinic, alpha-9 subunit|cholinergic receptor, nicotinic, alpha polypeptide 9|neuronal acetylcholine receptor protein, alpha-9 subunit|neuronal acetylcholine receptor subunit alpha-9|nicotinic acetylcholine receptor subunit alpha 9 |
Swissprots | Q4W5A2 Q9NYV2 Q14CY7 Q9UGM1 |
Accessions | AAM74523 AAY40986 EAW92963 Q9UGM1 AF227732 AAF61920 AJ243342 CAB65091 BC111595 AAI11596 BC113549 AAI13550 BC113575 AAI13576 BG218331 BP870578 HQ258272 ADR83026 NM_017581 NP_060051 |
Function | Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840). {ECO:0000269|PubMed:11021840, ECO:0000269|PubMed:11752216, ECO:0000269|PubMed:25282151, ECO:0000305}. |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:25282151}; Multi-pass membrane protein {ECO:0000305|PubMed:25282151}. |
Tissue Specificity | Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells. {ECO:0000269|PubMed:11021840, ECO:0000269|PubMed:11752216, ECO:0000269|PubMed:15531379}. |
Top Pathways | Neuroactive ligand-receptor interaction |
AChRα9 (A-15) - sc-13804 from Santa Cruz Biotechnology
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AChRα9 (E-17) - sc-13806 from Santa Cruz Biotechnology
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Anti-CHRNA9 antibody - ab177119 from Abcam
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Anti-CHRNA9 antibody - N-terminal - ab192193 from Abcam
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Anti-CHRNA9 Antibody (aa8-42) - LS-C344234 from LifeSpan Bioscience
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Anti-CHRNA9 Antibody (N-Terminus) IHC-plus™ - LS-B936 from LifeSpan Bioscience
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Nicotinic Acetylcholine R alpha 9/CHRNA9 Antibody - NBP1-79949 from Novus Biologicals
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Anti-CHRNA9 antibody produced in rabbit - AV13019 from Sigma-Aldrich
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CHRNA9 Antibody - N-terminal region (ARP35266_P050) - ARP35266_P050 from Aviva Systems Biology
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CHRNA9 antibody - N-terminal region (AVARP13019_P050) - AVARP13019_P050 from Aviva Systems Biology
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CHRNA9-Antibody-N-term - AP20598a from Abgent, a WuXi AppTec company
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CHRNA9-Antibody-N-term - AW5287 from Abgent, a WuXi AppTec company
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CHRNA9 Antibody - N-terminal region (OAAB18120) - OAAB18120 from Aviva Systems Biology
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CHRNA9 antibody - 70R-10540 from Fitzgerald
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CHRNA9 Antibody - abx037647 from Abbexa
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Neuronal acetylcholine receptor subunit alpha-9 antibody - 26025-1-AP from Acris Antibodies
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Neuronal acetylcholine receptor subunit alpha-9 antibody - H00055584-M01 from Acris Antibodies
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Rabbit Anti-Human CHRNA9 (N-term) - 102-14952 from RayBiotech
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CHRNA9 Antibody - 31-094 from ProSci
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CHRNA9 antibody - 26025-1-AP from Proteintech Group
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CHRNA9 Antibody - 39956 from Signalway Antibody
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CHRNA9 Antibody - E301763 from Enogene
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CHRNA9 Antibody - GWB-72D10E from Genway Biotech
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CHRNA9, Polyclonal Antibody - MBS417602 from MyBioSource
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Anti-CHRNA9 polyclonal antibody - DPABH-12340 from Creative Diagnostics
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