AMER1

Gene Symbol AMER1
Entrez Gene 139285
Alt Symbol FAM123B, OSCS, WTX
Species Human
Gene Type protein-coding
Description APC membrane recruitment protein 1
Other Description RP11-403E24.2|Wilms tumor gene on the X chromosome protein|Wilms tumor on the X|adenomatous polyposis coli membrane recruitment 1|family with sequence similarity 123B|protein FAM123B
Swissprots Q5JTC6 Q8N885 A2IB86
Accessions EAX05415 Q5JTC6 AK097146 BAC04964 AL833759 DA939151 EF186024 ABM60755 XM_011530858 XP_011529160 NM_152424 NP_689637
Function Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta- catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}.
Subcellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Translocates to the cell membrane following binding to PtdIns(4,5)P2.
Tissue Specificity Detected in fetal and adult kidney, brain and spleen. {ECO:0000269|PubMed:19416806}.

Human FAM123B ORF clone (NM_152424.3) - CDCR062526 from Creative biogene

Species Human

Human FAM123B cDNA Clone(NM_152424.3) - CDFG009461 from Creative biogene

Species Human
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