AMER1

Gene Symbol AMER1
Entrez Gene 139285
Alt Symbol FAM123B, OSCS, WTX
Species Human
Gene Type protein-coding
Description APC membrane recruitment protein 1
Other Description RP11-403E24.2|Wilms tumor gene on the X chromosome protein|Wilms tumor on the X|adenomatous polyposis coli membrane recruitment 1|family with sequence similarity 123B|protein FAM123B
Swissprots Q5JTC6 Q8N885 A2IB86
Accessions EAX05415 Q5JTC6 AK097146 BAC04964 AL833759 DA939151 EF186024 ABM60755 XM_011530858 XP_011529160 NM_152424 NP_689637
Function Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta- catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}.
Subcellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Translocates to the cell membrane following binding to PtdIns(4,5)P2.
Tissue Specificity Detected in fetal and adult kidney, brain and spleen. {ECO:0000269|PubMed:19416806}.

WTX CRISPR/Cas9 KO Plasmid (h) - sc-409039 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

WTX HDR Plasmid (h) - sc-409039-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WTX Double Nickase Plasmid (h) - sc-409039-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WTX Double Nickase Plasmid (h2) - sc-409039-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WTX CRISPR Activation Plasmid (h) - sc-409039-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

WTX CRISPR Activation Plasmid (h2) - sc-409039-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

WTX Lentiviral Activation Particles (h) - sc-409039-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WTX Lentiviral Activation Particles (h2) - sc-409039-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WTX siRNA (h) - sc-91345 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

WTX shRNA Plasmid (h) - sc-91345-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

WTX shRNA (h) Lentiviral Particles - sc-91345-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN8150 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8150 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

AMER1 siRNA (Human) - CRJ5249 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AMER1 - MBS8203236 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FAM123B (NM_152424.3) - SHH289377 from Creative biogene

Category siRNA
Species Reactivities Human

Human AMER1 siRNA - orb275750 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AMER1 shRNA Plasmid (Human) - CHJ5249 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FAM123B miRNA 3'UTR clone - MiUTR1H-03410 from Creative biogene

Species Reactivities Human
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