| Gene Symbol |
SPPL3
|
| Entrez Gene |
121665
|
| Alt Symbol |
IMP2, MDHV1887, PRO4332, PSH1, PSL4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
signal peptide peptidase like 3
|
| Other Description |
SPP-like 3|intramembrane protease 2|presenilin homologous protein 1|presenilin-like protein 4|signal peptide peptidase-like 3
|
| Swissprots |
Q3MJ04 Q96DD9 Q8TCT6 Q8TAU4
|
| Accessions |
CCQ43833 EAW98220 EAW98221 EAW98222 EAW98223 Q8TCT6 AB252457 BAF30928 AF086117 AI676074 AJ345030 CAC87791 AJ420898 CAD13135 AK074916 BAC11290 AK097149 AK223590 BAD97310 AK291161 BAF83850 AL110147 CAB53661 AY169313 AAO12538 AY358767 AAQ89127 BC009551 AAH09551 BC025781 AAH25781 BC073910 AAH73910 BC101625 AAI01626 BC101627 AAI01628 BU932077 XM_011537924 XP_011536226 XM_011537925 XP_011536227 NM_139015 NP_620584
|
| Function |
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. {ECO:0000269|PubMed:16873890}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Restricted to the early secretory compartment.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:15385547}.
|